The effects of L-threo-3,4-dihydroxyphenylserine on the total norepinephrine and dopamine concentrations in the cerebrospinal fluid and freezing gait in parkinsonian patients
We studied the effects of L-threo-DOPS (L-DOPS) on the concentrations of total (conjugated and unconjugated) dopamine (DA) and norepinephrine (NE) in the cerebrospinal fluid (CSF) of parkinsonian patients with freezing phenomenon. The NE concentration increased remarkably and dose-dependently after administration of L-DOPS in both L-dopa/carbidopa-pretreated and untreated patients. The DA concentration also increased mildly but significantly in L-dopa/carbidopa-untreated patients. Freezing phenomenon improved in 6 out of 8 patients at Hoehn and Yahr's stage III, and 1 out of 5 patients at stage IV. These results indicate that L-DOPS administration increases the NE concentration dosedependently, and is effective for freezing of gait of moderate severity.
KeywordsL-threo-DOPS freezing of gait norepinephrine dopamine cerebrospinal fluid
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- Lieberman A, Dziatolowski M, Gopinathan G, Kupersmith M, Neophytides A, Korein J (1980) Evaluation of Parkinson's disease. In: Goldstein M, Calne DB, Lieberman AN, Thorner MO (eds) Ergot compounds and brain function: neuroendocrine and neuropsychiatric aspects. Raven Press, New York, pp 277–286Google Scholar
- Nagatsu T, Kato T, Nagatsu I, Kondo Y, Inagaki S, Iizuka R, Narabayashi H (1979) Catecholamine related enzymes in the brain of patients with parkinsonism and Wilson's disease. Adv Neurol 24: 283–292Google Scholar
- Nagatsu T, Wakui Y, Kato T, Fujita K, Kondo T, Yokochi F, Narabayashi H (1982) Dopamine beta-hydroxylase activity in cerebrospinal fluid of Parkinsonian patients. Biomed Res 3: 95–98Google Scholar
- Narabayashi H, Kondo T (1987) Results of a double-blind study of L-threo-DOPS in parkinsonism. In: Fahn S, et al (eds) Recent developments in Parkinson's disease, vol II. Macmillan, New Jersey, pp 279–291Google Scholar
- Narabayashi H, Kondo T, Hayashi A, Suzuki T, Nagatsu T (1981) L-threo-3,4-dihydroxyphenylserine treatment for akinesia and freezing of parkinsonism. Proc Jpn Acad 57 (Ser B): 351–354Google Scholar
- Tohgi H, Abe S, Takahashi S, Takahashi J, Nozaki Y, Ueno M, Kikuchi T (1993) Monoamine metabolism in the cerebrospinal fluid in Parkinson's disease: relationship to clinical symptoms and subsequent therapeutic outcomes. J Neural Transm [P-D Sect] 5: 17–26Google Scholar