On the use of isofluorane as an anaesthetic for visual neurophysiology
Research Note
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Summary
The use of the anaesthetic isofluorane (ForeneR, Deutsche Abbott) for unit cell recordings from the monkey striate cortex is considered. Two aspects are emphasised; the maintenance of sustained components of response and the stability of vegetative physiology under isofluorane anaesthesia. A comparison of the use of isofluorane with halothane is made. The similar physical constants of isofluorane and halothane allow the easy adaptation of conventional delivery systems to use with isofluorane, when allowance is made for differences in anaesthetic strength.
Key words
Isofluorane Anaesthesia Visual neurophysiology Striate cortex Sustained responsesPreview
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References
- Atlee JL III, Alexander SC (1977) Halothane effects on conductivity of the AV node and His-Purkinje system in the dog. Anesth analg (Cleve) 56:378–386Google Scholar
- Byles PH, Dobkin AB, Ferguson JH (1971a) Forane (Compound 469)2: Biochemical effects of repeated administration to animals, response to bleeding and compatability with epinephrine. Can Anaesth Soc J 18:387–396PubMedGoogle Scholar
- Byles PH, Dobkin AB, Jones DB (1971b) Forane (Compound 469) 3: Comparative effects of prolonged anaesthesia on mature beagle dogs and young rhesus monkeys. Can Anaesth Soc J 18:397–407PubMedGoogle Scholar
- Christ DD, Satoh H, Kenna JG, Pohl LR (1988) Potential metabolic basis for enfluorane hepatitis and the apparent cross-sensitization between enfluorane and halothane. Drug Metab Dispos 16:135–140PubMedGoogle Scholar
- Cromwell TH, Eger EI (1971) Forane uptake, excretion, and blood solubility in man. Anaesthesiology 35:401–408Google Scholar
- Demoor A VON (1971) Ist Halothan eine inerte Substanz? Übersicht und eigene Untersuchungen. Berl Münch Tierartzl Wochenschr 100:181–187Google Scholar
- Dobkin AB, Byles PH, Ghanoon S, Valbuena DA (1971) Clinical and laboratory evaluation of a new inhalation anaesthetic: Forane (Compound 469) CHF2-O-CHCLF3 (1-chloro-2,2,2-trifluoroethyl difluoromethyl ether). Can Anaesth J 18:264–271Google Scholar
- Dobkin AB, Kim D, Choi JK (1973) Blood serum fluoride levels with enfluorane (Ethrane) and Isofluorane (Forane) anaesthesia during and following major abdominal surgery. Can Anaesth J 20:494–498Google Scholar
- Eger EI (1981a) Isofluorane: a review. Anaesthesiology 55:559–576Google Scholar
- Eger EI (1981b) Isofluorane (Forane): a compendium and reference. Ohio Medical Products, Madison WisconsinGoogle Scholar
- Eger EI, Smith NT, Stoelting RK (1970) Cardiovascular effects of halothane in man. Anesthesiology 32:396–409PubMedGoogle Scholar
- Gilbert M, Roberts SL, Mori M, Blomberg R, Tinker JH (1988) Comparative coronary vascular reactivity and hemodynamics during halothane and isofluorane anaesthesia in swine. Anesthesiology 68:243–253PubMedGoogle Scholar
- Graves CL, McDermott RW, Bidwai A (1974) Cardiovascular effects of isofluorane in surgical patients. Anesthesiology 41:486–489PubMedGoogle Scholar
- Hammond P (1978) Inadequacy of nitrous oxide/oxygen mixtures for maintaining anaesthesia in cats: satisfactory alternatives. Pain 5:143–151PubMedGoogle Scholar
- Harper MH, Johnson BH, Collins P (1980) Hepatic injury following halothane, enfluorane and isofluorane anaesthesia in rats. Anesthesiology 53:S242Google Scholar
- Harper MH, Collins P, Johnson B (1981) Decrease in hepatic blood flow may cause injury during halothane anesthesia. Anesth Analg (Cleve) 60:253–254Google Scholar
- Ikeda H, Wright MJ (1974) Sensitivity of neurones in visual cortex (Area 17) under different levels of anaesthesia. Exp Brain Res 20:471–484CrossRefPubMedGoogle Scholar
- Holaday Da, Fiserva-Bergerova V, Latto IP (1975) Resistance of isofluorane to biotransformation in Man. Anaesthesiology 43:325–332Google Scholar
- Horn J, Konchigeri HN, Eckenhof JE (1972) A new anaesthetic agent Forane; preliminary observations in Man. Anesth Analg (Cleve) 51:439–477Google Scholar
- Lee BB, Valberg A, Tigwell DA, Tryti J (1987) An account of responses of spectrally opponent neurones in macaque lateral geniculate nucleus to successive contrast. Proc R Sco (Lond) B 230:293–314Google Scholar
- Levy W (1982) Cardiac arrhythmias. Can Anaesth Soc J 29:SupplS28-S34Google Scholar
- Linde HW, Oh SO, Homi J (1975) Cardiovascular effects of isofluorane in surgical patients. Anaesthesiology 41:486–489Google Scholar
- Lynch C (1988) Effects of halothane and isofluorane on the isolated human ventricular myocardium. Anesthesiology 68:429–432PubMedGoogle Scholar
- Mallow JE, White RD, Cucchiara RF (1976) Hemodynamic effects of isofluorane and halothane in patients with coronary artery disease. Anesth Analg (Cleve) 55:135–138Google Scholar
- Miller RD, Eger EI, Way WL (1971a) Comparative neuromuscular effects of Forane and halothane alone and in combination with d-tubocurarine in man. Anesthesiology 35:38–42PubMedGoogle Scholar
- Miller RD, Way WL, Dolan WM, Stevens WC, Eger EI (1971b) Comparative neuromuscular effects of pancuronium, gallamine and succinylcholine during Forane and halothane anaesthesia in man. Anesthesiology 35:509–514PubMedGoogle Scholar
- Pauca AL, Dripps RD (1973) Clinical experience with isofluorane (Forane). Br J Anaesth 45:697–703PubMedGoogle Scholar
- Raj PP, Tod MJ, Jenkins MT (1967) Halothane biotransformation in Man: a quantitative study. Anaesthesiology 28:711–715Google Scholar
- Reyder K, Forbes J, Alter H (1967) Halothane biotransformation in Man: a quantitative study. Anesthesiology 28:711–715PubMedGoogle Scholar
- Richards CD, Webb AC (1975) The effect of nitrous oxide on cats anaesthetized with Brietal. J Physiol (Lond) 245:72–73PGoogle Scholar
- Russell WJ (1973) Nitrous oxide — is it an adequate anaesthetic? J Physiol (Lond) 231:20–21PGoogle Scholar
- Saidman LJ, Eger EI (1964) Effect of nitrous oxide and of narcotic premedication on the alveolar concentration of halothane required for anaesthesia. Anesthesiology 25:302–306PubMedGoogle Scholar
- Steffey EP (1980) Isoflurane concentration delivered by isofluorane and halothane-specific vapourizers. Anesthesiology 53:S19Google Scholar
- Steffey EP, Zinkel J, Howland D (1979) Minimal changes in blood cell counts and biochemical values associted with prolonged isofluorane anaesthesia of horses. Am J Vet Res 40:1646–1648PubMedGoogle Scholar
- Stevens WC, Cromwell TH, Halsey MJ (1971) Cardiovascular effects of a new inhalation anaesthetic, Forane, in human volunteers at constant arterial carbon dioxide tension. Anaesthesiology 35:8–16Google Scholar
- Stevens WC, Dolan WM, Gibbons RT, White A, Eger EI, Miller RD, de Jong RH, Elashoff RM (1975) Minimum alveolar concentrations (MAC) of isofluorane with and witout nitrous oxide in patients of various ages. Anesthesiology 42:197–200PubMedGoogle Scholar
- Stevens WC, Eger EI, White A (1975) Comparative toxicities of halothane, isofluorane and diethyl ether at sub-anaesthetic concentrations in laboratory animals. Anesthesiology 42:408–419PubMedGoogle Scholar
- Stevens WC, Eger EI, White A (1977) Comparative toxicities of enfluorane, fluroxene and nitrous oxide at sub-anaesthetic concentrations in laboratory animals. Can Anaesth Soc 24:479–490Google Scholar
- Suzuko H, Azuma M (1976) A glass-insulated “Elgiloy” microelectrode for recording unit activity in chronic monkey experiments. Electroenceph Clin Neurophysiol 41:93–95CrossRefPubMedGoogle Scholar
- Venes JL, Collins WF, Taub A (1971) Nitrous oxide, an anaesthetic for experiments in cats. Am J Physiol 220:2028–2031PubMedGoogle Scholar
- Wolfson B, Hetrick WD, Lake CL (1978) Anaesthetic indices — further data. Anaesthesiology 48:187–190Google Scholar
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