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Investigation of paths for the synthesis of 5,5-dialkyl-3-perfluoroalkyl-5,6-dihydro-1,2,4-triazolo[3,4-a]isoquinolines

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Abstract

Substituted 3-trifluoromethyl-5,6-dihydro-1,2,4-triazolo[3,4-a]isoquinolines were obtained by the reaction of substituted 1-methylthio-3,4-dihydroisoquinolines with hydrazine hydrate and trifluoroacetic acid. The corresponding 3-perfluoroalkyl derivatives are formed in the course of dehydration of 2-(3,3-dimethyl-3,4-dihydro-1-isoquinolyl)hydrazides of perfluorocarboxylic acids.

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Additional information

Institute of Technical Chemistry, Ural Branch, Russian Academy of Sciences, Perm. Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 3, pp. 380–386, March, 2000.

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Glushkov, V.A., Shklyaev, Y.V., Maiorova, O.A. et al. Investigation of paths for the synthesis of 5,5-dialkyl-3-perfluoroalkyl-5,6-dihydro-1,2,4-triazolo[3,4-a]isoquinolines. Chem Heterocycl Compd 36, 319–325 (2000). https://doi.org/10.1007/BF02256870

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Keywords

  • hydrazides
  • hydrazones
  • isoquinoline
  • 1,2,4-triazolo[3,4-a]isoquinoline
  • perfluorocarboxylic acids
  • perfluorocarboxylic esters