Substituted 3-trifluoromethyl-5,6-dihydro-1,2,4-triazolo[3,4-a]isoquinolines were obtained by the reaction of substituted 1-methylthio-3,4-dihydroisoquinolines with hydrazine hydrate and trifluoroacetic acid. The corresponding 3-perfluoroalkyl derivatives are formed in the course of dehydration of 2-(3,3-dimethyl-3,4-dihydro-1-isoquinolyl)hydrazides of perfluorocarboxylic acids.
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Glushkov, V.A., Shklyaev, Y.V., Maiorova, O.A. et al. Investigation of paths for the synthesis of 5,5-dialkyl-3-perfluoroalkyl-5,6-dihydro-1,2,4-triazolo[3,4-a]isoquinolines. Chem Heterocycl Compd 36, 319–325 (2000). https://doi.org/10.1007/BF02256870
- perfluorocarboxylic acids
- perfluorocarboxylic esters