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Isolated lung chemotherapeutic infusions for treatment of pulmonary metastases: A pilot study

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Abstract

A pilot study was designed to determine the feasibility of combining minimally invasive surgery techniques and cardiac surgical catheter technology to deliver high-dose unilateral pulmonary chemotherapy. Single lung ventilation general anesthesia was combined with catheter-based left pulmonary artery (PA) control in 4 mongrel dogs.p-Aminohippuric acid (PAH) was used to quantify leakage of pulmonary arterial infusate. Surgical exposure was progressively less invasive. Dissection of cranial and caudal pulmonary veins followed methods used in minimally invasive pulmonary lobectomy. All animals survived the experimental procedure. The Heart-Port Endoplege catheter controlled the canine PA. A volume (50 cm3) of infusate much smaller than the calculated pulmonary vascular volume caused less vascular over-distention and diffused throughout the pulmonary vascular bed within 3–5 min as verified by fluoroscopy. 75% of the tracer remained in the lung at the completion of the 30-min dwell time. The pulmonary circulation can be isolated by minimally invasive operative and catheter technology so that the pulmonary parenchyma can be exposed to a high concentration of a compound for at least 30 min in the canine model.

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Demmy, T.L., Wagner-Mann, C. & Allen, A. Isolated lung chemotherapeutic infusions for treatment of pulmonary metastases: A pilot study. J Biomed Sci 9, 334–338 (2002). https://doi.org/10.1007/BF02256589

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Key Words

  • High-dose chemotherapy
  • Lung perfusion
  • Pulmonary metastases
  • Selective lung perfusion
  • Video-assisted thoracic surgery