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Syphilis and squamous cell carcinoma of the stomach: A case report


Gastric syphilis and squamous cell carcinoma of the stomach are both rare conditions. Their simultaneous occurrence in this patient, however, may represent more than chance. This case documents that squamous cell carcinoma may arise in areas of squamous metaplasia. It also provides an opportunity to briefly review the clinical and radiologic findings in gastric syphilis and to stress the nonspecific nature of these findings.

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  1. 1.

    Symmers D: Anatomic lesions in late acquired syphilis; a study of 314 cases based on 4,880 necropsies at Bellevue Hospital.JAMA 66: 1457–1462, 1916

  2. 2.

    Singer HA, Meyer KA: Syphilis of the stomach with special reference to its incidence.Surg Gynec Obstet 48: 23–32, 1929

  3. 3.

    Eusterman GB, Balfour DC:The Stomach and Duodenum. Philadelphia: Saunders 1936

  4. 4.

    Eusterman GB: Gastric syphilis; observations based on 93 cases.JAMA 96: 173–179, 1931

  5. 5.

    Carman RD: Syphilis of the stomach in its roentgenologic aspects.Am J Syph 1: 111–116, 1917

  6. 6.

    Carman RD: Roentgenologic aspects of hour-glass stomach.Surg Gynec Obstet 27: 426–437, 1918

  7. 7.

    Mendl K, Jenkens RT, Hughes JR: Congenital and acquired syphilis of the stomach with special reference to gastric deformity in various stages, and report of 2 cases.Br J Radiol 29: 48–55, 1956

  8. 8.

    Wood DA: Adenocanthoma of the pyloric end of the stomach; a consideration of its histogenesis and report of 2 cases.Arch Pathol 36: 177–189, 1943

  9. 9.

    Hicks JD: Squamous cell carcinoma of the stomach.J Pathol 66: 570–572, 1953

  10. 10.

    Donald KJ: Adenocarcinoma of the pyloric antrum with extensive squamous differentiation.J Clin Pathol 20: 136–138, 1967

  11. 11.

    Altshuler JH, Shaka JA: Squamous cell carcinoma of the stomach.Cancer 19: 831–838, 1966

  12. 12.

    Herxheimer G: Über heterologe Canceroide.Beitr Pathol 41: 348–412, 1907

  13. 13.

    Morson BC, Dawson IMP:Gastrointestinal Pathology, p. 150. London: Blackwell Scientific Publications 1972

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Correspondence to David Rochester M.D..

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Rochester, D., Brosnan, J.J. & Straus, F.H. Syphilis and squamous cell carcinoma of the stomach: A case report. Gastrointest Radiol 1, 335–337 (1976).

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Key words

  • Stomach syphilis
  • Carcinoma of the stomach