Physical dependence on nicotine gum: effect of duration of use
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This study examined whether longer duration on nicotine gum promoted dependence on nicotine gum. Subjects (N=128) answering an advertisement for smoking cessation research and wanting to quit smoking cigarettes were randomly assigned to 1- or 3-month duration of nicotine gum use. Assessments were made weekly for smoking status (with biochemical verification) and withdrawal symptoms during and at the end of treatment. Follow-up was conducted at 1, 6 and 12 months to provide exploratory data on treatment outcome. The results showed minimal nicotine gum withdrawal symptoms after gum cessation with virtually no difference in gum withdrawal between the 1- and 3-month groups. Withdrawal symptoms from the nicotine gum included difficulty with concentration, increased variability on a reaction time task, and decreased vigor. The results also showed that continuous use of the gum at 1 year was observed in 1.5% of subjects and estimated to be as high as 14%. Finally, the 3-month group experienced a 2-fold increase in abstinence compared to the 1-month group, although this difference was not statistically significant. We conclude that there is minimal physical dependence on nicotine gum.
Key wordsNicotine gum Withdrawal signs Treatment outcome
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- Fagerstrom KO, Melin B (1985) Nicotine chewing gum in smoking cessation: efficiency, nicotine dependence, therapy duration, and clinical recommendations. In: Grabowski J, Hall SM (eds) Pharmacological adjuncts in smoking cessation. National Institute on Drug Abuse. Dept of Health and Human Services, Washington, DC, pp 102–109Google Scholar
- Hatsukami DK, Hughes JR, Pickens RW (1985) Blood nicotine, smoke exposure and tobacco withdrawal symptoms. Addict Behav 10:413–417Google Scholar
- McNair DM, Lorr M, Droppleman LF (1971) Manual for the profile of mood states. Educational and Industrial Testing Service, San DiegoGoogle Scholar
- Minnesota Heart Health Program (1989) Quit and win participant manual: consumers guide to smoking cessation. Minneapolis, MN Regent of the University of MinnesotaGoogle Scholar
- Russell M, Raw M, Jarvis MJ (1990) Clinical use of nicotine gum. BMJ 280:1599–1602Google Scholar
- Subcommittee of the Research Committee of the British Thoracic Society (1983) Comparison of four methods of smoking withdrawal in patients with smoking related diseases. BMJ 286:595–597Google Scholar
- USDHHS (1988) The health consequences of smoking; nicotine addiction. A report of the surgeon general. US Government Printing Office. DHHS publication no 88-8406Google Scholar
- Woods MN (1992) Current issues in the use of dietary assessment. Health Psychol 11 [Supplement]:45–46Google Scholar
- Yellin AMA (1980) Standard visual stimulus for use in studies of attention and attention deficit disorders: toward the development standardized and selective attention tests. Res Commun Psychol Psych Behav 5:137–143Google Scholar