Journal of Biomedical Science

, Volume 5, Issue 1, pp 24–27 | Cite as

Tat, Tat-associated kinase, and transcription

  • Kuan-Teh Jeang


The HIV-1 Tat protein is an RNA-binding transcriptional transactivator. Recent findings suggest that Tat associates with a cellular kinase that phosphorylates the carboxyl-terminal domain of the largest subunit of RNA polymerase II. Here we review, in brief, the role of Tat-associated kinase in Tat-activated transcription. We discuss evidence that suggests involvement of TFIIH and/or P-TEFb.

Key Words

Human immunodeficiency virus Tat Transcription Sp1 RNA polymerase II Protein kinase 


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Copyright information

© National Science Council 1998

Authors and Affiliations

  • Kuan-Teh Jeang
    • 1
  1. 1.Molecular Virology SectionLaboratory of Molecular Microbiology, NIAID, NIHBethesdaUSA

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