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Synthesis of pyrroloquinolines from 2,3-dimethyl-5-methoxy-6-aminoindole

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Formation of enaminoketones, enaminocrotonate, and aminomethylenemalonate from 2,3-dimethyl-5-methoxy-6-aminoindole occurs significantly less easily than for the 7-methoxy analog. A similar dependence is observed in the reaction of enamines to the corresponding pyrroloquinolines independently of the cyclization conditions.

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  1. 1.

    S. A. Yamashkin, N. Ya. Kucherenko, and M. A. Yurovskaya, Khim. Geterotsikl. Soedin., No. 1, 75 (1997).

  2. 2.

    S. A. Yamashkin, L. G. Yudin, and A. N. Kost, Khim. Geterotsikl. Soedin., No. 4, 493 (1983).

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M. E. Evsev'eva Moldavian State Teaching Institute, Saransk 430007. M. V. Lomonosov State University, Moscow 119899. Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 7, pp. 941–945, July, 1997.

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Yamashkin, S.A., Kucherenko, N.Y. & Yurovskaya, M.A. Synthesis of pyrroloquinolines from 2,3-dimethyl-5-methoxy-6-aminoindole. Chem Heterocycl Compd 33, 823–827 (1997).

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  • Organic Chemistry
  • Cyclization Condition
  • Similar Dependence
  • Enamine
  • Pyrroloquinolines