, Volume 28, Issue 1, pp 22–26 | Cite as

Effects of active substances fromStaphylococcus aureus (protein a and peptidoglycan) on neurotransmitter-induced contractions of smooth muscles

  • I. B. Filippov
  • M. F. Shuba
  • T. L. Davydovskaya
  • L. S. Kholodnaya
  • V. K. Pozur
  • T. A. Lyubchenko


Modulatory effects of protein A (PA) and peptidoglycan (PG) fromStaphylococcus aureus on the smooth muscle contractions elicited by neurotransmitters were studied. PA and PG were found to suppress the myometrium smooth muscle contractions elicited by acetylcholine applications. The effects of the substances on the contractions were due to non-competitive inhibition through an enhancement of the potassium-dependent conductance of the smooth muscle cell membrane. PA and PG did not affect the myometrium contractions elicited by oxytocin, or the contractions of the coronary arteries elicited by acetylcholine or noradrenaline.


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Copyright information

© Plenum Publishing Corporation 1997

Authors and Affiliations

  • I. B. Filippov
    • 1
  • M. F. Shuba
    • 1
  • T. L. Davydovskaya
    • 2
  • L. S. Kholodnaya
    • 2
  • V. K. Pozur
    • 2
  • T. A. Lyubchenko
    • 2
  1. 1.Bogomolets Institute of PhysiologyNational Academy of Sciences of UkraineKievUkraine
  2. 2.Shevchenko UniversityKievUkraine

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