Psychopharmacology

, Volume 114, Issue 3, pp 505–508 | Cite as

Effect of ambient temperature on hyperthermia and hyperkinesis induced by 3,4-methylenedioxymethamphetamine (MDMA or “ecstasy”) in rats

  • Richard Ian Dafters
Original Investigations

Abstract

A stress-free, biotelemetric monitoring technique was used to investigate the effects of ambient temperature (Ta) on the hyperthermic and hyperkinetic effects of 3,4-methylenedioxymethamphetamine. In the first experiment a single injection of 5.0 or 7.5 mg/kg MDMA produced hyperthermia in rats maintained at aTa of 24°C but hypothermia in rats maintained at aTa of 11°C for 24 h prior to the injection. In contrast, hyperkinesis was induced at bothTas. In the second experiment, the effects of acute MDMA administration was compared in rats maintained at a standardTa of 24°C and in rats which were placed in a cool (11°C) room for a brief (90-min) period commencing 30 min after the injection. The brief exposure to the cool environment produced significant attenuation of MDMA-induced hyperthermia but did not affect the magnitude of hyperkinesis. The implications of the results for the understanding of the thermotoxic effects of MDMA in human drug users are discussed.

Key words

MDMA Hyperthermia Hyperkinesis Ambient temperature 

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Copyright information

© Springer-Verlag 1994

Authors and Affiliations

  • Richard Ian Dafters
    • 1
  1. 1.Psychology DepartmentGlasgow UniversityGlasgowUK

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