Clinical Rheumatology

, Volume 16, Issue 2, pp 167–172

The determination of pyridinium crosslinks in urine and serum as a possible marker of cartilage degradation in rheumatoid arthritis

  • G. Hein
  • S. Franke
  • A. Muller
  • E. Bräunig
  • T. Eidner
  • G. Stein
Originals

DOI: 10.1007/BF02247846

Cite this article as:
Hein, G., Franke, S., Muller, A. et al. Clin Rheumatol (1997) 16: 167. doi:10.1007/BF02247846

Summary

The determination of the collagen crosslinks pyridinoline (Pyd) and deoxypyridinoline (Dpyd) seems to be a successful way of characterizing topic destructive processes in rheumatoid arthritis (RA). Dpyd is a specific marker of collagen I resorption in bone, whereas Pyd is released from types I and II collagen in bone and cartilage. Both crosslinks were examined in 38 RA patients concurrently by RP-gradient-HPLC in urine and serum. A positive correlation was found between the inflammatory activity (measured by CrP) and the level of collagen crosslinks in urine. A correlation between serum and urine concentrations was demonstrable for Pyd, but not for Dpyd. Different elimination kinetics for fragments containing either Pyd or Dpyd are a possible explanation for this observation. The ratio of Pyd/Dpyd is known to be a useful marker to distinguish between destruction of cartilage and bone collagen. Because the Pyd/Dpyd ratio in urine does not necessarily correspond to that in serum, probably as a result of metabolic or elimination processes, the usefulness of the relationship between the crosslinks in urine as a method of differentiating between cartilage and bone degradation must be questioned.

Key words

Rheumatoid Arthritis Cartilage Degradation Collagen Crosslinks Pyridinium Compounds 

Copyright information

© Clinical Rheumatology 1997

Authors and Affiliations

  • G. Hein
    • 1
  • S. Franke
    • 1
  • A. Muller
    • 1
  • E. Bräunig
    • 1
  • T. Eidner
    • 1
  • G. Stein
    • 1
  1. 1.Department of Internal Medicine IVFriedrich Schiller University JenaGermany
  2. 2.Department of Internal Medicine IVRheumatology & OsteologyJenaGermany

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