Psychopharmacology

, Volume 116, Issue 4, pp 437–442

The atypical antipsychotic, remoxipride, blocks phencyclidine-induced disruption of prepulse inhibition in the rat

  • Christina Johansson
  • David M Jackson
  • Lennart Svensson
Article

DOI: 10.1007/BF02247475

Cite this article as:
Johansson, C., Jackson, D.M. & Svensson, L. Psychopharmacology (1994) 116: 437. doi:10.1007/BF02247475

Abstract

The effect of various typical (haloperidol) and atypical (clozapine, raclopride, remoxipride) antipsychotics on phencyclidine (PCP)-induced disruption of sensorimotor gating was tested in rats using an acoustic startle paradigm. Clozapine (4–40 µmol/kg), haloperidol (1–5 µmol/kg) and raclopride (1–12 µmol/kg) failed to reverse PCP-induced disruption of prepulse inhibition (PPI) of the acoustic startle response. In contrast, remoxipride (12–60 µmol/kg) caused a dose-dependent block of this effect. PCP-induced disruption of PPI is a widely accepted animal model of a corresponding behavioural deficit observed in schizophrenia although little evidence has been presented that it is in fact sensitive to antipsychotic agents. The present results indicate that remoxipride behaves in a unique way in this model compared to clozapine, haloperidol and raclopride.

Key words

Antipsychotic agents Acoustic startle Prepulse inhibition Schizophrenia Phencyclidine Remoxipride Rat 

Copyright information

© Springer-Verlag 1994

Authors and Affiliations

  • Christina Johansson
    • 2
  • David M Jackson
    • 2
  • Lennart Svensson
    • 1
  1. 1.Department of PharmacologyUniversity of GöteborgGöteborgSweden
  2. 2.Department of Behavioural PharmacologyCNS Preclinical Research and Development, Astra Arcus ABSödertäljeSweden

Personalised recommendations