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Psychopharmacology

, Volume 108, Issue 4, pp 417–431 | Cite as

Nicotinic systems and cognitive function

  • Edward D. Levin
Original Investigations

Abstract

Nicotinic acetylcholine receptors have been found to be important for maintaining optimal performance on a variety of cognitive tasks. In humans, nicotine-induced improvement of rapid information processing is particularly well documented. In experimental animals nicotine has been found to improve learning and memory on a variety of tasks, while the nicotinic antagonist mecamylamine has been found to impair memory performance. Nicotine has been found to be effective in attenuating memory deficits resulting from lesions of the septohippocampal pathway or aging in experimental animals. Nicotinic receptors are decreased in the cortex of patients with Alzheimer's disease. Preliminary studies have found that some aspects of the cognitive deficit in Alzheimer's disease can be attenuated by nicotine. Nicotine may prove to be useful therapeutic treatment for this and other types of dementia.

Key words

Acetylcholine Nicotinic Memory Nicotine Mecamylamine 

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References

  1. Abelin T, Buehler A, Muller P, Vesanen K, Imhof PR (1989) Controlled trial of transdermal nicotine patch in tobacco withdrawal. Lancet 1:7–10Google Scholar
  2. Ahtee L, Kaakkola S (1978) Effect of mecamylamine on the fate of dopamine in striatal and mesolimbic areas of rat brain. Interaction with morphine and haloperidol. Br J Pharmacol 62:213–218Google Scholar
  3. Aizenman E, Tang LH, Reynolds IJ (1991) Effects of nicotinic agonists on the NMDA receptor. Brain Res 551:355–357Google Scholar
  4. Amador M, Dani JA (1991) MK-801 inhibition of nicotinic acetylcholine receptor channels. Synapse 7:207–215Google Scholar
  5. Andersson K, Hockey GRJ (1977) Effects of cigarette smoking on incidental memory. Psychopharmacology 52:223–226Google Scholar
  6. Andersson K, Post B (1974) Effects of cigarette smoking on verbal note learning and physiological arousal. Scand J Psychol 15:263–267Google Scholar
  7. Appel SH (1981) Alzheimer's disease. In: Enna SJ, Samorajski T, Beer B (eds) Brain neurotransmitters and receptors in aging and age-related disorders. Raven Press, New York, pp 203–207Google Scholar
  8. Araujo DM, Lapchak PA, Robitaille Y, Gauthier S, Quirion R (1988) Differential alteration of various cholinergic markers in cortical and subcortical regions of human brain in Alzheimer's disease. J Neurochem 50:1914–1923Google Scholar
  9. Avis HH, Pert A (1974) A comparison of the effects of muscarinic and nicotinic anticholinergic drugs on habituation and fear conditioning in rats. Psychopharmacology 34:209–222Google Scholar
  10. Balfour D, Graham CA, Vale AL (1986) Studies on the possible role of brain 5-HT systems and adrenocortical activity in behavioural responses to nicotine and diazepam in an elevated X-maze. Psychopharmacology 90:528–532Google Scholar
  11. Balfour DJK (1990) A comparison of the effects of nicotine and (+)-amphetamine on rat behaviour in an unsignalled Sidman avoidance schedule. J Pharm Pharmacol 42:257–260Google Scholar
  12. Bammer G (1982) Pharmacological investigations of neurotransmitter involvement in passive avoidance responding: a review and some new results. Neurosci Biobehav Rev 6:247–296Google Scholar
  13. Barclay L, Kheyfets S (1989) Tobacco use in Alzheimer's disease. In: Alzheimer's disease and related disorders. Liss, New York, pp 189–194Google Scholar
  14. Barrios V, Rodriguez-Sanchez MN, Colas B, Arilla E (1990) Effects of acute nicotine and mecamylamine administration on somatostatin concentration and binding in the rat brain. Eur J Pharmacol 179:263–270Google Scholar
  15. Bartus RT, Dean RL, Flicker C (1987) Cholinergic psychopharmacology: an integration of human and animal research on memory. In: Meltzer HY (ed) Psychopharmacology: the third generation of progress. Raven Press, New York, pp 219–232Google Scholar
  16. Bättig K (1970) The effect of pre- and post-trial application of nicotine on the 12 problems of Hebb-Williams test in the rat. Psychopharmacologia 18:68–76Google Scholar
  17. Beani L, Bianchi C, Ferraro L, Nilsson L, Nordberg A, Romanelli L, Spalluto P, Sundwall A, Tanganelli S (1989) Effect of nicotine on the release of acetylcholine and amino acids in the brain. Prog Brain Res 79:149–155Google Scholar
  18. Blozovski D (1983) Deficits in passive avoidance learning in young rats following mecamylamine injections in the hippocampo-entorhinal area. Exp Brain Res 50:442–448Google Scholar
  19. Blozovski D, Dumery V (1987) Development of amygdaloid cholinergic mediation of passive avoidance learning in the rat. Exp Brain Res 67:70–76Google Scholar
  20. Bovet D, Bover-Nitti F, Oliviero A (1966) Effects of nicotine on avoidance conditioning in inbred strains of mice. Psychopharmacologia 10:1–5Google Scholar
  21. Bovet-Nitti F (1966) Facilitation of simultaneous visual discrimination by nicotine in the rat. Psychopharmacologia 10:59–66Google Scholar
  22. Bovet-Nitti F (1969) Facilitation of simultaneous visual discrimination by nicotine in four inbred strains of mice. Psychopharmacologia 14:193–199Google Scholar
  23. Brazell MP, Mitchell SN, Gray JA (1991) Effect of acute administration of nicotine on in vivo release of noradrenaline in the hippocampus of freely moving rats: a dose-response and antagonist study. Neuropharmacology 30:823–833Google Scholar
  24. Buccafusco JJ, Jackson WJ (1991) Beneficial effects of nicotine administered prior to a delayed matching-to-sample task in young and aged monkeys. Neurobiol Aging 12:233–238Google Scholar
  25. Buchkremer G, Minneker E (1989) Efficiency of multimodal smoking cessation therapy combining transdermal nicotine substitution with behavioral therapy. Methods Find Exp Clin Pharmacol 11:215–218Google Scholar
  26. Castellano C (1976) Effects of nicotine on discrimination learning, consolidation and learned behaviour in two inbred strains of mice. Psychopharmacology 48:37–43Google Scholar
  27. Chiappeta L, Jarvik ME (1969) Comparison of learning impairment and activity depression produced by two classes of cholinergic blocking agents. Arch Int Pharmacodyn 179:161–166Google Scholar
  28. Clarke PBS (1987) Nicotine and smoking: a perspective from animal studies. Psychopharmacology 92:135–143Google Scholar
  29. Clarke PBS, Fibiger HC (1990) Reinforced alternation performance is impaired by muscarinic but not by nicotinic receptor blockade in rats. Behav Brain Res 36:203–207Google Scholar
  30. Clarke PBS, Pert A (1985) Autoradiographic evidence for nicotine receptors on nigrostriatal and mesolimbic dopaminergic neurons. Brain Res 348:355–358Google Scholar
  31. Clarke PBS, Pert CB, Pert A (1984) Autoradiographic distribution of nicotine receptors in rat brain. Brain Res 323:390–395Google Scholar
  32. Clarke PBS, Hommer DW, Pert A, Skirboll LR (1985) Electrophysiological actions of nicotine on substantia nigra single units. Br J Pharmacol 85:827–835Google Scholar
  33. Clarke PBS, Hommer DW, Pert A, Skirboll LR (1987) Innervation of substantia nigra neurons by cholinergic afferents from pedunculopontine nucleus in the rat: neuroanatomical and electrophysiological evidence. Neuroscience 23:1011–1019Google Scholar
  34. Collerton D (1986) Cholinergic function and intellectual decline in Alzheimer's disease. Neuroscience 19:1–28Google Scholar
  35. Cregan E, Ordy JM, Palmer E, Blosser J, Wengenack T, Thomas G (1989) Spatial working memory enhancement by nicotine of aged long Evans rats in the T-maze. Soc Neurosci Abstr 15:731Google Scholar
  36. Decker MW, Majchrzak MJ (1991) Nicotine-induced attenuation of spatial memory deficits in rats with septal lesions. Abstr Soc Neurosci 17:1235Google Scholar
  37. Decker MW, Majchrzak MJ (1992) The effects of systemic and intracerebroventricular administration of mecamylamine, a nicotinic cholinergic antagonist, on spatial memory in rats. Psychopharmacology 107:530–534Google Scholar
  38. DeSarno P, Giacobini E, Clark B (1988) Changes in nicotinic receptors in human and rat CNS. Fed Proc 2:364Google Scholar
  39. Dilsaver SC, Peck JA, Overstreet DH (1991) The Flinders sensitive line exhibits enhanced thermic responseness to nicotine relative to the Sprague-Dawley rat. Pharmacol Biochem Behav 41:23–27Google Scholar
  40. Diltz SL, Berry CA (1967) Effect of cholinergic drugs on passive avoidance in the mouse. J Pharmacol Exp Ther 158:279–285Google Scholar
  41. Dunne MP, MacDonald D, Hartley LR (1986) The effects of nicotine upon memory and problem solving performance. Physiol Behav 37:849–854Google Scholar
  42. Dunnett SB, Martel FL (1990) Proactive interference effects on short-term memory in rats: 1. Basic parameters and drug effects. Behav Neurosci 104:655–665Google Scholar
  43. Elrod K, Buccafusco JJ (1991) Correlation of the amnestic effects of nicotinic antagonists with inhibition of regional brain acetylcholine synthesis in rats. J Pharmacol Exp Ther 258:403–409Google Scholar
  44. Elrod K, Buccafusco JJ, Jackson WJ (1988) Nicotine enhances delayed matching-to-sample performance by primates. Life Sci 43:277–287Google Scholar
  45. Erickson CK (1971) Studies on the mechanism of avoidance facilitation by nicotine. Psychopharmacologia 22:357–368Google Scholar
  46. Essman WB, Essman SG (1971) Cholinergic mechanisms and avoidance behavior acquisition: effects of nicotine in mice. Psychol Rep 29:987–993Google Scholar
  47. Evangelista AM, Izquirierdo I (1972) Effects of atropine on avoidance condition: interaction with nicotine and comparison with N-methyl-atropine. Psychopharmacologia 27:241–248Google Scholar
  48. Evangelista AM, Gattoni RC, Izquierdo I (1970) Effect of amphetamine, nicotine and hexamethonium on performance of a conditioned response during acquisition and retention trials. Pharmacology 3:91–96Google Scholar
  49. Flynn DD, Mash DC (1986) Characterization ofl-[3H]nicotine binding in human cerebral cortex: comparison between Alzheimer's disease and the normal. J Neurochem 47:1948–1954Google Scholar
  50. French LR, Schuman LM, Mortimer JA, Hutton JT, Boatman RA, Christians B (1985) A case-control study of dementia of the Alzheimer's type. Am J Epidemiol 121:414–421Google Scholar
  51. Freund RK, Jungschaffer DA, Collins AC, Wehner JM (1988) Evidence for modulation of GABAergic neurotransmission by nicotine. Brain Res 453:215–220Google Scholar
  52. Garg M (1969) The effect of nicotine on two different types of learning. Psychopharmacologia 15:408–414Google Scholar
  53. Garg M, Holland HC (1968) Consolidation and maze learning: a further study of post-trial injection of a stimulant drug (nicotine). Int J Neuropharmacol 7:55–58Google Scholar
  54. Garg M, Holland HC (1969) Consolidation and maze larning. A study of some strain/drug interactions. Psychopharmacologia 14:426–431Google Scholar
  55. Giacobini E, DeSarno P, McIlhany M, Clark B (1988) The cholinergic receptor system in the frontal lobe of Alzheimer's patients. In: Clementi F, Gotti C, Sher E (eds) Nicotinic acetylcholine receptors in the nervous system. Springer, Berlin Heidelberg New York, pp 367–378Google Scholar
  56. Giacobini E, DeSarno P, Clark B, McIlhany M (1989) The cholinergic receptor system of the human brain. Neurochemical and pharmacological aspects of aging and Alzheimer. In: Nordberg A (ed) Progress in brain research. Elsevier, Amsterdam, pp 335–343Google Scholar
  57. Gilliam DM, Schlesinger K (1985) Nicotine-produced relearning deficit in C57B1/6J and DBA/2J mice. Psychopharmacology 86:291–295Google Scholar
  58. Glick SD, Greenstein S (1972) Differential effects of scopolamine and mecamylamine on passive avoidance behavior. Life Sci 11:169–179Google Scholar
  59. Goldberg ME, Sledge K, Hefner M, Robichaud RC (1971) Learning impairment after three classes of agents which modify cholinergic function. Arch Int Pharmacodyn 193:226–235Google Scholar
  60. Grenhoff J, Aston-Jones G, Svensson TH (1986) Nicotinic effects on the firing pattern of midbrain dopamine neurons. Acta Physiol Scand 128:151–158Google Scholar
  61. Haikala H, Ahtee L (1988) Antagonism of the nicotine-induced changes of the striatal dopamine metabolism in mice by mecamylamine and pempidine. Naunyn-Schmiedberg's Arch Pharmacol 338:169–173Google Scholar
  62. Haroutunian V, Barnes E, Davis KL (1985) Cholinergic modulation of memory in rats. Psychopharmacology 87:266–271Google Scholar
  63. Hatsukami D, Fletcher L, Morgan S, Keenan R, Amble P (1989) The effects of varying cigarette deprivation duration on cognitive and performance tasks. J Subt Abuse 1:407–416Google Scholar
  64. Heyman A, Wilkinson WE, Stafford JA, Helms MJ, Sigmon AH, Weinberg T (1984) Alzheimer's disease: a study of epidemiological aspects. Ann Neurol 15:335–341Google Scholar
  65. Hodges H, Allen Y, Sinden J, Lantons PL, Gray JA (1991a) Effects of cholinergic-rich neural grafts on radial maze performance after excitotoxic lesions of the forebrain cholinergic projection system — II. Cholinergic drugs as probes to investigate lesion-induced deficits and transplant-induced functional recovery. Neuroscience 45:609–623Google Scholar
  66. Hodges H, Gray JA, Allen Y, Sinden J (1991b) The role of the forebrain cholinergic projection system in performance in the radial-arm maze in memory-impaired rats. In: Adlkofer F, Thurau K (eds) Effects of nicotine on biological systems. Birkhäuser Verlag, Boston, pp 389–399Google Scholar
  67. Hodges H, Sinden J, Turner JJ, Netto CA, Sowinski P, Gray JA (1992) Nicotine as a tool to characterise the role of the forebrain cholinergic projection system in cognition. In: Lippiello PM, Collins AC, Gray JA, Robinson JH (eds) The biology of nicotine: current research issues. Raven Press, New York, pp 157–182Google Scholar
  68. Houston JP, Schneider NG, Jarvik ME (1978) Effects of smoking on free recall and organization. Am J Psychiatry 135:220–222Google Scholar
  69. Hunter B, Zornetzer SF, Jarvik ME, McGaugh JL (1977) Modulation of learning and memory: effects of drugs influencing neurotransmitters. In: Iversen LL, Iversen SD, Snyder SH (eds) Handbook of psychopharmacology. Plenum Press, New YorkGoogle Scholar
  70. Imperato A, Mulas A, Di Chiara G (1986) Nicotine preferentially stimulates dopamine release in the limbic system of freely moving rats. Eur J Pharmacol 132:337–338Google Scholar
  71. Jackson WJ, Buccafusco JJ (1989) Nicotinic enhancement of delayed matching by monkeys is specific to the most difficult problems. Soc Neurosci Abstr 15:731Google Scholar
  72. Jackson WJ, Elron K, Buccafusco JJ (1989) Delayed matching-to-sample in monkeys as a model for learning and memory deficits: role of brain nicotinic receptors. In: Meyer EM, Simpkins JW, Yamamoto J (eds) Novel approaches to the treatment of Alzheimer's disease. Plenum Press, New York, pp 39–52Google Scholar
  73. Jones GMM, Reith M, Philpot MP, Sahakian BJ (1987) Smoking and dementia of Alzheimer type. J Neurol Neurosurg Psychiatry 50:1383Google Scholar
  74. Joseph MH, Peters SL, Prior A, Mitchell SN, Brazell MP, Gray JA (1990) Chronic nicotine administration increases tyrosine hydroxylase selectively in the rat hippocampus. Neurochem Int 16:269–273Google Scholar
  75. Kellar KJ, Wonnacott S (1990) Nicotinic cholinergic receptors in Alzheimer's disease. In: Wonnacott S, Russell MAH, Stolerman IP (eds) Nicotine psychopharmacology: molecular, cellular, and behavioral aspects. Oxford University Press, Oxford, pp 341–373Google Scholar
  76. Krumpe P, Malani N, Adler J, Ramoorthy S, Asadi S, Corwin N, Dolan P, Geismar L (1989) Efficacy of transdermal nicotine as an adjunct for smoking cessation in heavily nicotine addicted smokers. Am Rev Resp Dis 139:A337Google Scholar
  77. Ksir C, Hakan R, Hall DP, Kellar KJ (1985) Exposure to nicotine enhances the behavioral stimulant effect of nicotine and increases binding of3H-acetylcholine to nicotinic receptors. Neuropharmacology 24:527–531Google Scholar
  78. Ksir C, Hakan RL, Kellar KJ (1987) Chronic nicotine and locomotor activity. Influences of exposure dose and test dose. Psychopharmacology 92:25–29Google Scholar
  79. Lapchak PA, Araujo DM, Quirion R, Collier B (1989) Effect of chronic nicotine treatment on nicotinic autoreceptor function and N-[3H]methylcarbamylcholine binding sites in the rat brain. J Neurochem 52:483–491Google Scholar
  80. Lapin EP, Maker HS, Sershen H, Lajtha A (1989) Action of nicotine on accumbens dopamine and attenuation with repeated administration. Eur J Pharmacol 160:53–59Google Scholar
  81. Levin ED (1988a) Psychopharmacological effects in the radial-arm maze. Neurosci Biobehav Rev 12:169–175Google Scholar
  82. Levin ED (1988b) Scopolamine interactions with D1 and D2 antagonists on radial-arm maze performance in rats. Behav Neural Biol 50:240–245Google Scholar
  83. Levin ED, Rose JE (1990) Anticholinergic sensitivity following chronic nicotine administration as measured by radial-arm maze performance in rats. Behav Pharmacol 1:511–520Google Scholar
  84. Levin ED, Rose JE (1991) Nicotinic and muscarinic interactions and choice accuracy in the radial-arm maze. Brain Res Bull 27:125–128Google Scholar
  85. Levin ED, Russell RW (1992) Nicotinic-muscarinic interactions in cognitive function. In: Levin ED, Decker MW, Butcher LL (eds) Neurotransmitter interactions and cognitive function. Birkhäuser, Boston (in press)Google Scholar
  86. Levin ED, Castonguay M, Ellison GD (1987a) Effects of the nicotinic receptor blocker, mecamylamine, on radial arm maze performance in rats. Behav Neural Biol 48:206–212Google Scholar
  87. Levin ED, Morgan MM, Galvez C, Ellison GD (1987b) Chronic nicotine effects on food and water intake and weight regulation in rats. Physiol Behav 39:441–444Google Scholar
  88. Levin ED, McGurk SR, Rose JE, Butcher LL (1989a) Reversal of a mecamylamine-induced cognitive deficit with the D2 agonist, LY 171555. Pharmacol Biochem Behav 33:919–922Google Scholar
  89. Levin ED, McGurk SR, South D, Butcher LL (1989b) Effects of combined muscarinic and nicotinic blockade on choice accuracy in the radial-arm maze. Behav Neural Biol 51:270–277Google Scholar
  90. Levin ED, Lee C, Rose JE, Reyes A, Ellison G, Jaravik M, Gritz E (1990a) Chronic nicotine and withdrawal effects on radial-arm maze performance in rats. Behav Neural Biol 53:269–276Google Scholar
  91. Levin ED, Rose JE, McGurk SR, Butcher LL (1990b) Characterization of the cognitive effects of combined muscarinic and nicotinic blockade. Behav Neural Biol 53:103–112Google Scholar
  92. Levin ED, Briggs SJ, Christopher NC, Rose JE (1992a) Nicotine-mecamylamine interactions and radial-arm maze performance in rats. Soc Neurosci Abstr (in press)Google Scholar
  93. Levin ED, Briggs SJ, Christopher NC, Rose JE (1992b) Persistence of chronic nicotine-induced cognitive facilitation. Behav Neural Biol (in press)Google Scholar
  94. Levin ED, Christopher NC, Briggs S, Rose JE (1992c) Nicotine attenuates radial-arm maze choice accuracy deficits after fimbria lesions. British Association for Psychopharmacology and European Behavioural Pharmacology Society Joint MeetingGoogle Scholar
  95. Lichtensteiger W, Hefti F, Felix D, Huwyler T, Melamed E, Schlumpf M (1982) Stimulation of nigrostriatal dopamine neurons by nicotine. Neuropharmacology 21:963–968Google Scholar
  96. London ED, Ball MJ, Waller SB (1989) Nicotinic binding sites in cerebral cortex and hippocampus in Alzheimer's disease. Neurochem Res 14:745–750Google Scholar
  97. MacLeod NK, James TA, Starr MS (1984) Muscarinic action of acetylcholine in the rat ventromedial thalamic nucleus. Exp Brain Res 55:553–561Google Scholar
  98. Marks MJ, Burch JB, Collins AC (1983) Effects of chronic nicotine infusion on tolerance development and nicotine receptors. J Pharmacol Exp Ther 226:817–825Google Scholar
  99. Marks MJ, Stitzel JA, Collins AC (1985) Time course study of the effects of chronic nicotine infusion on drug response and brain receptors. J Pharmacol Exp Ther 235:619–628Google Scholar
  100. Marks MJ, Romm E, Campbell SM, Collins AC (1989a) Variation of nicotinic binding sites among inbred strains. Pharmacol Biochem Behav 33:679–689Google Scholar
  101. Marks MJ, Stitzel JA, Collins AC (1989b) Genetic influences on nicotine responses. Pharmacol Biochem Behav 33:667–668Google Scholar
  102. McGurk SR, Levin ED, Butcher LL (1989a) Nicotinic-dopaminergic relationships and radial-arm maze performance in rats. Behav Neural Biol 52:78–86Google Scholar
  103. McGurk SR, Levin ED, Butcher LL (1989b) Radial-arm maze performance in rats is impaired by a combination of nicotinic-cholinergic and D2 dopaminergic drugs. Psychopharmacology 99:371–373Google Scholar
  104. Meru G, Yoon KP, Boi V, Gessa GL, Naes L, Westfall TC (1987) Preferential stimulation of ventral tegmental area dopaminergic neurons by nicotine. Eur J Pharmacol 141:395–399Google Scholar
  105. Miner LL, Collins AC (1989) Strain comparisons of nicotine-induced seizure sensitivity and nicotinic receptors. Pharmacol Biochem Behav 33:469–475Google Scholar
  106. Mitchell SN, Smith KM, Joseph MH, Gray JA (1992) Acute and chronic effects of nicotine on catecholamine synthesis and release in the rat central nervous system. In: Lippiello PM, Collins AC, Gray JA, Robinson JH (eds) The biology of nicotine: current research issues. Raven Press, New York, pp 97–119Google Scholar
  107. Morrison CF (1974a) Effects of nicotine and its withdrawal on the performance of rats on signalled and unsignalled avoidance schedules. Psychopharmacologia 38:25–35Google Scholar
  108. Morrison CF (1974b) Effects of nicotine on the observed behaviour of rats during signalled and unsignalled avoidance schedules. Psychopharmacologia 38:37–46Google Scholar
  109. Mulligan SC, Masterson JG, Devane JG, Kelly JG (1990) Clinical and pharmacokinetic properties of a transdermal nicotine patch. Clin Pharmacol Ther 47:331–337Google Scholar
  110. Mundy WR, Iwamoto ET (1988a) Actions of nicotine on the acquisition of an autoshaped lever-touch response in rats. Psychopharmacology 94:267–274Google Scholar
  111. Mundy WR, Iwamoto ET (1988b) Nicotine impairs acquisition of radial-arm maze performance in rats. Pharmacol Biochem Behav 40:119–122Google Scholar
  112. Nanry KP, Mundy WR, Tilson HA (1989) Colchicine-induced alterations of reference memory in rats: role of spatial versus non-spatial task components. Behav Brain Res 35:45–53Google Scholar
  113. Nelsen JM (1978) Psychobiological consequences of chronic nicotinization: A focus on arousal. In: Bättig K (ed) Behavioral effects of nicotine. Karger, Basel, pp 1–17Google Scholar
  114. Newhouse PA, Hughes JR (1991) The role of nicotine and nicotinic mechanisms in neuropsychiatric disease. Br J Addict 86:521–526Google Scholar
  115. Newhouse PA, Sunderland T, Thompson K, Tariot PN, Weingartner H, Mueller ER, Cohen RM, Murphy DL (1986) Intravenous nicotine in a patient with Alzheimer's disease. Am J Psychiatry 143:1494–1495Google Scholar
  116. Newhouse PA, Sunderland T, Tariot PN, Blumhardt CL, Weingartner H, Mellow A, Murphy DL (1988) Intravenous nicotine in Alzheimer's disease: a pilot study. Psychopharmacology 95:171–175Google Scholar
  117. Nordberg A, Bergh C (1985) Effect of nicotine on passive avoidance behavior and motoric activity in mice. Acta Pharmacol Toxicol 56:337–341Google Scholar
  118. Nordberg A, Winblad B (1986) Reduced number of3H-nicotine and3H-acetylcholine binding sites in the frontal cortex of Alzheimer brains. Neurosci Lett 72:115–119Google Scholar
  119. Nordberg A, Adem A, Hardy J, Winblad B (1988) Change in nicotinic receptor subtypes in temporal cortex of Alzheimer brains. Neurosci Lett 88:317–321Google Scholar
  120. O'Dell TJ, Christensen BN (1988) Mecamylamine is a selective non-competitive antagonist of N-methyl-d-aspartate- and aspartate-induced currents in horizontal cells dissociated from the catfish retina. Neurosci Lett 94:93–98Google Scholar
  121. Ochoa ELM, Chattopadhyay A, McNamee MG (1988) Desensitization of the nicotinic acetylcholine receptor: molecular mechanisms and effect of modulators. Cell Mol Neurobiol 9:141–178Google Scholar
  122. Oliverio A (1966) Effects of mecamylamine on avoidance conditioning and maze learning of mice. J Pharmacol Exp Ther 154:350–356Google Scholar
  123. Oliverio A (1968) Effects of nicotine and strychnine on transfer of avoidance learning in the mouse. Life Sci 7:1163–1167Google Scholar
  124. Orsingher OA, Fulginiti S (1971) Effects of alpha-methyl-tyrosine and adrenergic blocking agents on the faciliting action of amphetamine and nicotine on learning in rats. Psychopharmacologia 19:231–240Google Scholar
  125. Peeke SC, Peeke HVS (1984) Attention, memory, and cigarette smoking. Psychopharmacology 84:205–216Google Scholar
  126. Perry EK (1987) Cortical neurotransmitter chemistry in Alzheimer's disease. In: Meltzer HY (ed) Psychopharmacology: the third generation of progress. Raven Press, New York, pp 887–895Google Scholar
  127. Perry EK, Curtis M, Dick DJ, Candy JM, Atack JR, Bloxham CA, Blessed G, Fairbairn A, Tomlinson BE, Perry RH (1985) Cholinergic correlates of cognitive impairment in Parkinson's disease: comparisons with Alzheimer's disease. J Neurol Neurosurg Psychiatry 48:413–421Google Scholar
  128. Perry EK, Perry RH, Smith CJ, Dick DJ, Candy JM, Edwardson JA, Fairbairn A, Blessed G (1987) Nicotinic receptor abnormalities in Alzheimer's and Parkinson's diseases. J Neurol Neurosurg Psychiatry 50:806–809Google Scholar
  129. Peters R, McGee R (1982) Cigarette smoking and state-dependent learning. Psychopharmacology 76:232–235Google Scholar
  130. Pradhan SN (1970) Effects of nicotine on several schedules of behavior in rats. Arch Int Pharmacodyn 183:127–138Google Scholar
  131. Provost SC, Woodward R (1991) Effects of nicotine gum on repeated administration of the Stroop test. Psychopharmacology 104:536–540Google Scholar
  132. Quiron R, Martel JC, Robitaille Y, Etienne P, Wood P, Nair NPV, Gauthier S (1986) Neurotransmitter and receptor deficits in senile dementia of the Alzheimer's type. Can J Neurol Sci 13:503–510Google Scholar
  133. Ramoa AS, Alkondon M, Aracava Y, Irons J, Lunt GG, Deshpande SS, Wonnacot S, Aronstam RS, Albuquerque EX (1990) The anticonvulsant MK-801 interacts with peripheral and central nicotinic acetylcholine receptor ion channels. J Pharmacol Exp Ther 254:71–82Google Scholar
  134. Rapier C, Lunt GG, Wonnacott S (1988) Stereoselective nicotine-induced release of dopamine from striatal synaptosomes: concentration dependence and repetitive stimulation. J Neurochem 50:1123–1130Google Scholar
  135. Reilly MA, Lapin EP, Maker HS, Lajtha A (1987) Chronic nicotine administration increases binding of [3H]domperidone in rat nucleus accumbens. J Neurosci Res 18:621–625Google Scholar
  136. Riekkinen P Jr, Sirviö J, Aaltonen M, Riekkinen P (1990) Effects of concurrent manipulations of nicotinic and muscarinic receptors on spatial and passive avoidance learning. Pharmacol Biochem Behav 37:405–410Google Scholar
  137. Rinne JO, Myllykylä T, Lönnberg P, Marjamäki P (1991) A post-mortem study of brain nicotinic receptors in Parkinson's and Alzheimer's disease. Brain Res 547:167–170Google Scholar
  138. Robinson GS Jr, Crooks GB Jr, Shinkman PG, Gallagher M (1989) Behavioral effects of MK-801 mimic deficits associated with hippocampal damage. Psychobiology 17:156–164Google Scholar
  139. Rose JE (1986) Transdermal nicotine as a strategy for nicotine replacement. In: Okene JK (ed) The pharmacologic treatment of tobacco dependence: Proceedings of the World Congress. Institute for the Study of Smoking Behavior and Policy, Cambridge, MA, pp 158–166Google Scholar
  140. Rose JE, Jarvik ME, Rose KD (1984) Transdermal administration of nicotine. Drug Alcohol Depend 13:209–213Google Scholar
  141. Rose JE, Herskovic JE, Trilling Y, Jarvik ME (1985) Transdermal nicotine reduces cigarette craving and nicotine preference. Clin Pharmacol Ther 38:450–456Google Scholar
  142. Rose JE, Levin ED, Behm FM, Adivi C, Schur C (1990) Transdermal nicotine facilitates smoking cessation. Clin Pharmacol Ther 47:323–330Google Scholar
  143. Roth N, Lutiger B, Hasenfratz M, Bättig K, Knye M (1992) Smoking deprivation in “early” and “late” smokers and memory function. Psychopharmacology 106:253–260Google Scholar
  144. Rowell RP, Carr LA, Garner AC (1987) Stimulation of [3H] dopamine release by nicotine in rat nucleus accumbens. J Neurochem 49:1449–1454Google Scholar
  145. Rupniak NMJ, Steventon MJ, Field MJ, Jennings C, Iversen SD (1989) Comparison of the effects of four cholinomimetic agents on cognition in primates following disruption by scopolamine or by lists of objects. Psychopharmacology 99:189–195Google Scholar
  146. Sahakian B, Jones G, Levy R, Gray J, Warburton D (1989) The effects of nicotine on attention, information processing, and short-term memory in patients with dementia of Alzheimer type. Br J Psychiatry 154:797–800Google Scholar
  147. Sansone M, Castellano C, M. B, Ammassari-Teule M (1990) Oxiracetam prevents mecamylamine-induced impairment of active, but not passive, avoidance learning in mice. Pharmacol Biochem Behav 36:389–392Google Scholar
  148. Sansone M, Castellano C, Battaglia M, Ammassari-Teule M (1991) Effects of oxiracetam-nicotine combinations on active and passive avoidance learning in mice. Pharmacol Biochem Behav 39:197–200Google Scholar
  149. Sasaki H, Yanai M, Meguro K, Sekizawa K, Ikarashi Y, Maruyama Y, Yamamoto M, Matsuzaki Y, Takishima T (1991) Nicotine improves cognitive disturbance in rodents fed with a choline-deficient diet. Pharmacol Biochem Behav 38:921–925Google Scholar
  150. Schröder H, Giacobini E, Struble RG, Zilles K, Maelicke A (1991) Nicotinic cholinoceptive neurons of the frontal cortex are reuced in Alzheimer's disease. Neurobiol Aging 12:259–262Google Scholar
  151. Schwartz RD (1986) Autoradiographic distribution of high affinity muscarinic and nicotinic cholinergic receptors labeled with [3H]acetylcholine in rat brain. Life Sci 38:2111–2119Google Scholar
  152. Schwartz RD, Kellar KJ (1983) Nicotinic cholinergic binding sites in the brain: in vivo regulation. Science 220:214–216Google Scholar
  153. Schwartz RD, Kellar KJ (1985) In vivo regulation of [3H]acetylcholine recognition sites in brain by nicotinic cholinergic drugs. J Neurochem 45:427–433Google Scholar
  154. Shalat SL, Seltzer B, Pidcock C, Baker EL (1987) Risk factors for Alzheimer's disease. Neurology 37:1630–1633Google Scholar
  155. Shimohama S, Taniguchi T, Fujiwara M, Kameyama M (1986) Changes in nicotinic and muscarinic receptors in Alzheimer-type dementia. J Neurochem 46:288–293Google Scholar
  156. Sjak-Shie NN, Meyer EM, Hunter BE (1991) Some novel actions of nicotine in nucleus basalis. In: Becker R, Giacobini E (eds) Cholinergic basis for Alzheimer therapy. Birkhäuser, Boston, pp 379–385Google Scholar
  157. Smith KM, Joseph MH, Gray JA (1991) A single dose of nicotine is sufficient to increase tyrosine hydroxylase activity in noradrenergic neurones. In: Adlkofer F, Thurau K (eds) Effects of nicotine on biological systems. Birkhäuser, Boston, pp 345–350Google Scholar
  158. Snell LD, Johnson KM (1989) Effects of nicotinic agonist and antagonists on N-methyl-d-aspartate-induced3H-norepinephrine release and3H-(1-(1-(2-thienyl)cyclohexyl)-piperidine) binding in rat hippocampus. Synapse 3:129–135Google Scholar
  159. Stolerman IP, Goldfarb T, Fink R, Jarvik ME (1973) Influencing cigarette smoking with nicotine antagonists. Psychopharmacology 28:247–259Google Scholar
  160. Sugaya K, Giacobini E, Chiappinelli VA (1990) Nicotinic acetylcholine receptor subtypes in human frontal cortex: changes in Alzheimer's disease. J Neurosci Res 27:349–359Google Scholar
  161. Tilson HA, McLamb RL, Shaw S, Rogers BC, Pediatikakis P, Cook L (1988) Radial-arm maze deficits produced by colchicine administered into the area of the nucleus basalis are ameliorated by cholinergic agonists. Brain Res 438:83–94Google Scholar
  162. Warburton DM (1992) Nicotine as a cognitive enhancer. Prog Neuropsychopharmacol Biol Psychiatry 16:181–919Google Scholar
  163. Warburton DM, Wesnes K (1984) Mechanisms for habitual substance use: Food, alcohol and cigarettes. In: Ale A, Edwards JA (eds) Physiological correlates of human behaviour, vol 1: basic issues. Academic Press, London, pp 277–297Google Scholar
  164. Warburton DM, Wesnes K, Shergold K, James M (1986) Facilitation of learning and state dependency with nicotine. Psychopharmacology 89:55–59Google Scholar
  165. Welzl H, Alessandri B, Oettinger R, Bättig K (1988) The effects of long-term nicotine treatment on locomotion, exploration and memory in young and old rats. Psychopharmacology 96:317–323Google Scholar
  166. Wesnes K, Warburton DM (1978) Effects of cigarette smoking and nicotine tablets upon human attention. In: Thornton RE (ed) Smoking behaviour: physiological and psychological influences. Churchill Livingstone, Edinburgh, pp 131–147Google Scholar
  167. Wesnes K, Warburton DM (1983) Smoking, nicotine and human performance. Pharmacol Ther 21:189–208Google Scholar
  168. Wesnes K, Warburton DM (1984) Effects of scopolamine and nicotine on human rapid information processing performance. Psychopharmacology 82:147–150Google Scholar
  169. Wesnes K, Warburton DM, Matz B (1983) Effects of nicotine on stimulus sensitivity and response bias in a visual vigilance task. Neuropsychobiology 9:41–44Google Scholar
  170. West R, Hack S (1991) Effect of cigarettes on memory search and subjective ratings. Pharmacol Biochem Behav 38:281–286Google Scholar
  171. Whitehouse PJ, Marrtino AM, Antuono PG, Lowenstein PR, Coyle JT, Price DL, Kellar KJ (1986) Nicotinic acetylcholine binding sites in Alzheimer's disease. Brain Res 371:146–151Google Scholar
  172. Whitehouse PJ, Martino AM, Marcus KA, Zweig RM, Singer HS, Price DL, Kellar KJ (1988a) Reductions in acetylcholine and nicotine binding in several degenerative iseases. Arch Neurol 45:722–724Google Scholar
  173. Whitehouse PJ, Martino AM, Wagster MV, Price DL, Mayeux R, Atack JR, Kellar KJ (1988b) Reductions in [3H]nicotinic acetylcholine binding in Alzheimer's disease and Parkinson's disease: an autoradiographic study. Neurology 38:720–723Google Scholar
  174. Williams DG (1980) Effects of cigarette smoking on immediate memory and performance in different kinds of smokers. Br J Psychol 71:83–90Google Scholar
  175. Wonnacott S (1990) The paradox of nicotinic acetylcholine receptor upregulation by nicotine. TIPS 11:216–219Google Scholar
  176. Wonnacott S, Irons J, Rapier C, Thorne B, Lunt GG (1989) Presynaptic modulation of transmitter release by nicotinic receptors. In: Nordberg A, Fuxe K, Holmstedt B, Sundwall A (eds) Progress in brain research. Elsevier, pp 157–163Google Scholar
  177. Wraight KB, Weldon E, Gupta BD, Holland HC (1967) The effects of post-trial injections of nicotine on the learning of an underwater discrimination task by rats. Anim Behav 15:287–290Google Scholar
  178. Yamanaka K, Oshita M, Muramatsu I (1985) Alterations of alpha and muscarinic receptors in rat brain and heart following chronic nicotine treatment. Brain Res 348:241–248Google Scholar
  179. Yamanaka K, Muramatsu I, Kigoshi S (1987) Muscarinic agonist binding in rat brain following chronic nicotine treatment. Brain Res 409:395–397Google Scholar
  180. Zhang ZW, Feltz P (1991) Bicuculline blocks nicotinic acetylcholine response in isolated intermediate lobe cells of the pig. Br J Pharmacol 102:19–22Google Scholar

Copyright information

© Springer-Verlag 1992

Authors and Affiliations

  • Edward D. Levin
    • 1
  1. 1.Nicotine Research Laboratory, Department of PsychiatryDuke University Medical CenterDurhamUSA

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