Psychopharmacology

, Volume 112, Issue 1, pp 142–144 | Cite as

Attenuation of some alcohol-induced mood changes and the desire to drink by 5-HT3 receptor blockade: a preliminary study in healthy male volunteers

  • B. A. Johnson
  • G. M. Campling
  • P. Griffiths
  • P. J. Cowen
Original Investigations

Abstract

We studied the effect of the 5-HT3 receptor antagonist ondansetron (4 mg orally) on some of the psychological effects of a small dose of alcohol (580 ml of 3.6% alcohol content by volume of lager) in 16 healthy male volunteers using a double-blind placebo controlled, Latin Square cross-over design. Pretreatment with ondansetron significantly attenuated several of the subjective pleasurable effects of alcohol, and also decreased the subjective desire to drink. These findings are consistent with preclinical studies suggesting that the reinforcing properties of alcohol may be attenuated by 5-HT3 receptor blockade.

Key words

Alcohol 5-HT3 receptors Ondansetron Reinforcement 

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Copyright information

© Springer-Verlag 1993

Authors and Affiliations

  • B. A. Johnson
    • 1
  • G. M. Campling
    • 1
  • P. Griffiths
    • 2
  • P. J. Cowen
    • 1
  1. 1.Oxford University Department of Psychiatry and MRC Unit of Clinical Pharmacology, Littlemore HospitalOxfordUK
  2. 2.Oxford University Computing ServicesOxfordUK

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