Psychopharmacology

, Volume 124, Issue 3, pp 285–287

Prolactin plasma levels and D2-dopamine receptor occupancy measured with IBZM-SPECT

  • S. Schlegel
  • R. Schlösser
  • C. Hiemke
  • O. Nickel
  • A. Bockisch
  • K. Hahn
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DOI: 10.1007/BF02246671

Cite this article as:
Schlegel, S., Schlösser, R., Hiemke, C. et al. Psychopharmacology (1996) 124: 285. doi:10.1007/BF02246671

Abstract

By the application of123([123I]IBZM), an iodine-labelled dopamine D2-receptor antagonist, brain D2 receptors in humans can be visualized with single photon emission computed tomography (SPECT). The ratio of IBZM binding to striatal regions versus binding to frontal cortex (ST/FC ratio) provided a semiquantitative measurement of D2 receptor binding in the striatum. This study investigated the relationship between receptor occupancy and plasma prolactin levels in 12 male patients treated with haloperidol, benperidol or clozapine. Prolactin levels were positively correlated with D2 receptor occupancy, reflecting at least in part a comparable dopamine receptor antagonism in different dopaminergic pathways.

Key words

123Iodobenzamide ([123I]IBZM) Single photon emission computed tomography (SPECT) Dopamine-D2-receptor Prolactin 

Copyright information

© Springer-Verlag 1996

Authors and Affiliations

  • S. Schlegel
    • 1
  • R. Schlösser
    • 1
  • C. Hiemke
    • 1
  • O. Nickel
    • 2
  • A. Bockisch
    • 2
  • K. Hahn
    • 2
  1. 1.Department of PsychiatryUniversity of MainzMainzGermany
  2. 2.Department of Nuclear MedicineUniversity of MainzMainzGermany

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