Psychopharmacology

, Volume 123, Issue 4, pp 303–306 | Cite as

Self-administration of the D1 agonist SKF 82958 is mediated by D1, not D2, receptors

  • D. W. Self
  • J. D. Belluzzi
  • S. Kossuth
  • L. Stein
Original Investigation

Abstract

We have previously reported that two D1 dopamine agonists, SKF 82958 and SKF 77434, are readily self-administered by rats. However, due to the limited selectivities of these agents, it was not possible to attribute their reinforcing effects exclusively to their D1 actions. To assess the relative involvement of D1 and D2 receptors in SKF 82958 reinforcement, rats were pretreated 30 min before self-administration sessions with either the D1-selective antagonist (+)SCH 23390 or the D2-selective antagonist raclopride. The D1 antagonist (+)SCH 23390 (5–20 µg/kg, SC) produced significant, dose-related (compensatory) increases in SKF 82958; in contrast, the D2 antagonist raclopride (25–400 µg/kg, SC) did not significantly increase SKF 82958 self-administration, although raclopride did increase cocaine self-administration. Compensatory increases in self-administration rates are thought to reflect antagonist-induced reductions in drug reinforcement. Hence, we conclude that SKF 82958 self-administration depends on activation of a D1-regulated reinforcement substrate.

Key words

Self-administration Dopamine Reinforcement SKF 82958 D1 agonists SCH 23390 D1 antagonists Raclopride D2 antagonists Cocaine 

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References

  1. Anderson PH, Jansen JA (1990) Dopamine receptor agonists: selectivity and dopamine D1 receptor efficacy. Eur J Pharmacol 188: 335–347Google Scholar
  2. Belluzzi JD, Kossuth SR, Lam D, Derakhshanfar F, Shin A, Stein L (1993) Cocaine self-administration patterns: duplication by combination of dopamine D1 and D2 agonists. Soc Neurosci Abstr 19: 1862Google Scholar
  3. Britton DR, Mackenzie RG, Kebabian JW, Williams JEG, Kerkmen D (1991) Evidence for involvement of both D1 and D2 receptors in maintaining cocaine self-administration. Pharmacol Biochem Behav 39: 911–915Google Scholar
  4. Caine SB, Koob GF (1993) Modulation of cocaine self-administration in the rat through D-3 dopamine receptors. Science 260: 1814–1816Google Scholar
  5. Caine SB, Koob GF (1994) Effects of dopamine D-1 and D-2 antagonists on cocaine self-administration under different schedules of reinforcement in the rat. J Pharmacol Exp Ther 270: 209–218Google Scholar
  6. Caine SB, Lintz R, Koob GF (1993) Intravenous drug self-administration techniques in animals. In: Sahgal A (ed) Behavioural neuroscience, vol. ii, a practical approach. Oxford University Press, Oxford, pp 117–143Google Scholar
  7. Cohen AI, Todd RD, Harmon S, O'Malley KL (1992) Photoreceptors of mouse retinas possess D4 receptors coupled to adenylate cyclase. Proc Natl Acad Sci 89: 12093–12097Google Scholar
  8. Davis MW, Smith SG (1977) Catecholaminergic mechanisms of reinforcement: direct assessment by drug self-administration. Life Sci 20: 483–492Google Scholar
  9. DeWit H, Wise RA (1977) Blockade of cocaine reinforcement in rats with the dopamine receptor blocker pimozide but not with noradrenergic blockers phentolamine and phenoxybenzamine. Can J Psychol 31: 195–203Google Scholar
  10. Hubner CB, Moreton JE (1991) Effects of selective D1 and D2 dopamine antagonists on cocaine self-administration in the rat. Psychopharmacology 105: 151–156Google Scholar
  11. Kebabian JW, Calne DB (1979) Multiple receptors for dopamine. Nature 277: 93–96Google Scholar
  12. Koob GF, Bloom FE (1988) Cellular and molecular mechanisms of drug dependence. Science 242: 715–723Google Scholar
  13. Koob GF, Goeders NE (1989) Neuroanatomical substrates of drug self-administration. In: Liebman JM, Cooper SJ (eds) The neuropharmacological basis of reward. Clarendon, Oxford, pp 214–263Google Scholar
  14. Koob GF, Le HT, Creese I (1987) The D1 dopamine receptor antagonist SCH 23390 increases cocaine self-administration in the rat. Neurosci Lett 79: 315–320Google Scholar
  15. Murray AM, Waddington JL (1989) The induction of grooming and vacuous chewing by a series of selective D-1 dopamine receptor agonists: two directions of D1: D2 interaction. Eur J Pharmacol 160: 377–384Google Scholar
  16. Potenza MN, Graminsky GF, Schmauss C, Lerner MR (1994) Functional expression and characterization of human D2 and D3 dopamine receptors. J Neurosci 14: 1463–1476Google Scholar
  17. Risner ME, Jones BE (1980) Intravenous self-administration of cocaine and norcaine by dogs. Psychopharmacology 71: 83–89Google Scholar
  18. Roberts DCS, Vickers G (1984) Atypical neuroleptics increase self-administration of cocaine: an evaluation of a behavioral screen for antipsychotic activity. Psychopharmacology 82: 135–139Google Scholar
  19. Roberts DCS, Corcoran ME, Fibiger HC (1977) On the role of ascending catecholaminergic systems in intravenous self-administration of cocaine. Pharmacol Biochem Behav 6: 616–620Google Scholar
  20. Self DW, Stein L (1992a) Receptor subtypes in opioid and stimulant reward. Pharmacol Toxicol 70: 87–94Google Scholar
  21. Self DW, Stein L (1992b) The D1 agonists SKF 82958 and SKF 77434 are self-administered by rats. Brain Res 582: 349–352Google Scholar
  22. Sibley DR, Monsma FJ Jr (1992) Molecular biology of dopamine receptors. Trends Pharmacol Sci 13: 61–69Google Scholar
  23. Weed MR, Vanover KE, Woolverton WL (1993) Reinforcing effects of the D1 dopamine agonist SKF 81297 in rhesus monkeys. Psychopharmacology 113: 51–52Google Scholar
  24. Wise RA, Rompre PP (1989) Brain dopamine and reward. Annu Rev Psychol 40: 191–225Google Scholar
  25. Wise RA, Murray A, Bozarth MA (1990) Bromocriptine self-administration and bromocriptine reinstatement of cocaine-trained and heroin-trained lever pressing in rats. Psychopharmacology 100: 355–360Google Scholar
  26. Woolverton WL (1986) Effects of a D1 and a D2 dopamine antagonist on the self-administration of cocaine and piribedil by rhesus monkeys. Pharmacol Biochem Behav 24: 531–535Google Scholar
  27. Woolverton WL, Goldberg LI, Ginos JZ (1984) Intravenous self-administration of dopamine receptor agonists by rhesus monkeys. J Pharmacol Exp Ther 230: 678–683Google Scholar
  28. Yokel RA, Wise RA (1978) Amphetamine-type reinforcement by dopaminergic agonists in the rat. Psychopharmacology 58: 289–296Google Scholar

Copyright information

© Springer-Verlag 1996

Authors and Affiliations

  • D. W. Self
    • 1
  • J. D. Belluzzi
    • 2
  • S. Kossuth
    • 2
  • L. Stein
    • 2
  1. 1.Department of Pharmacology, College of MedicineUniversity of CaliforniaIrvineUSA
  2. 2.Laboratory of Molecular Psychiatry, Department of PsychiatryYale University School of Medicine and Connecticut Mental Health CenterNew HavenUSA

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