Sixty-eight patients participated in this double-blind randomised study with moclobemide versus placebo (35 allocated to moclobemide; 33 to placebo). In terms of mean HAMD total scores, improvement tended to be more pronounced in the moclobemide group at treatment end-point. Efficacy was judged to be ‘very good’ or ‘good’ in 50% of moclobemide-treated patients and in 27% of placebo-treated patients: in completers only, the difference was more marked (69% versus 33%;P<0.05 Mann-Whitney test). Tolerability was judged to be ‘very good’ or ‘good’ in 77% of moclobemide-treated patients and in 94% of placebo-treated patients. Adverse events were observed in 31% of patients in the moclobemide group and in 18% of patients in the placebo group.
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Ose, E., Holm, P. Moclobemide and placebo in mild major depression: a double-blind randomized trial. Psychopharmacology 106, S114–S115 (1992). https://doi.org/10.1007/BF02246251