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Psychopharmacology

, Volume 106, Supplement 1, pp S35–S36 | Cite as

Interaction of moclobemide and tricyclic antidepressants with the tyramine pressor effect in rats

  • W. Burkard
  • F. d'Agostini
  • R. Kettler
  • M. Da Prada
Section I RIMA: Pharmacology, Biochemistry And Interactions Mini-Paper

Abstract

Tyramine at high doses (20 mg/kg) increased arterial blood pressure in freely moving rats. This increase was completely prevented by pretreatment with inhibitors of neuronal membrane carriers for noradrenaline (e.g. desipramine or oxaprotiline). Pretreatment with moclobemide induced a mild potentiation of this tyramine-pressor effect which could also be attenuated dose-dependently by co-administration of oxaprotiline.

Key words

Interaction Blood pressure MAO-A inhibitors MAO-B inhibitors 

References

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Copyright information

© Springer-Verlag 1992

Authors and Affiliations

  • W. Burkard
    • 1
  • F. d'Agostini
    • 1
  • R. Kettler
    • 1
  • M. Da Prada
    • 1
  1. 1.Pharmaceutical Research DepartmentF. Hoffmann-La Roche LtdBaselSwitzerland

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