, Volume 122, Issue 2, pp 115–121 | Cite as

Bretazenil modulates sleep EEG and nocturnal hormone secretion in normal men

  • J. Guldner
  • L. Trachsel
  • C. Kratschmayr
  • B. Rothe
  • F. Holsboer
  • A. Steiger
Original Investigation


Preclinical data suggest that the imidazo-diazepinone derivative bretazenil (Ro 16-6028) has anxiolytic and anticonvulsant properties with only weak sedative effects. We examined the influence of oral administration of 1 mg bretazenil on the sleep EEG and the concomitant nocturnal secretion of cortisol, growth hormone and prolactin in ten healthy young men. After bretazenil we found a significant increase in stage 2 sleep and a significant reduction in stage 3 sleep. REM latency was prolonged. Spectral analysis of sleep-EEG power revealed a decrease in delta and in theta power and an increase in sigma power. We found no significant influence on sleep onset latency or on intermittent wakefulness. Bretazenil prompted a significant decrease in cortisol secretion and a significant increase in prolactin release. It had no major influence on growth hormone secretion.

Key words

Bretazenil Sleep EEG Cortisol Growth hormone Prolactin GABA benzodiazepine receptor EEG power spectra 


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Copyright information

© Springer-Verlag 1995

Authors and Affiliations

  • J. Guldner
    • 1
  • L. Trachsel
    • 1
  • C. Kratschmayr
    • 1
  • B. Rothe
    • 1
  • F. Holsboer
    • 1
  • A. Steiger
    • 1
  1. 1.Max Planck Institute of PsychiatryClinical Institute, Department of PsychiatryMunichGermany

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