, Volume 104, Issue 4, pp 470–474 | Cite as

Effect on smoking cessation of silver acetate, nicotine and ordinary chewing gum

Influence of smoking history
  • E. J. Jensen
  • E. Schmidt
  • B. Pedersen
  • R. Dahl
Original Investigations


In a randomized smoking cessation study 211, 203 and 82 persons were supported with nicotine, silver acetate and ordinary chewing gum, respectively. After 26 weeks there was no overall difference in number of abstainers between treatments. Participants were divided into subsets with low and high weighted packyears consumption (WPY) which modifies tobacco consumption by nicotine content. Abstainer rates in the total population controlled for treatment decreased with increasing WPY (P<0.005). In participants with low WPY abstainer rate was higher in the silver acetate group compared to the nicotine (P<0.0005) and ordinary (P<0.05) chewing gum groups. Nicotine chewing gum was more effective than silver acetate (P<0.05) and ordinary (P<0.05) chewing gum in smokers with high WPY. Ratings on some inconveniences experienced during earlier attempts to quit smoking influenced the ability to break the habit but had no influence on chewing gum effects. This study indicated that through consideration of smoking history it should be possible to individualize pharmacological support to smokers wanting to quit, with silver acetate chewing gum most effective for smokers with a low WPY and nicotine chewing gum most effective for smokers with a high WPY.

Key words

Smoking Silver acetate Nicotine Chewing gum 


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  1. BMDP Statistical Software (1985) University of California Press, Los AngelesGoogle Scholar
  2. Cherry N, Kirnan K. Personality scores and smoking behaviour. A longitudinal study. Br J Soc Med 1976; 30:123–131Google Scholar
  3. Cummings KM, Giovino G, Jaen CR, Emrich LJ (1985) Reports of smoking withdrawal symptoms over a 21 day period of abstinence. Addict Behav 10:373–381Google Scholar
  4. Cummings KM, Jaen CR, Giovino G (1985) Circumstances surrounding relapse in a grup of recent ex-smokers. Prevent Med 14:373–381Google Scholar
  5. Fagerstrom KO (1982) A Comparison of psychological and pharmacological treatment in smoking cessation. J Behav Med 5:343–351Google Scholar
  6. Fagerstrom KO (1984) Effects of nicotine chewing gum and follow-up appointments in physician-based smoking cessation. Prevent Med 13:517–527Google Scholar
  7. Fee WM, Steward MJ (1982) A controlled trial of nicotine chewing gum in a smoking withdrawal clinic. Practitioner 226:148–151Google Scholar
  8. Fielding JE (1985) Smoking: health effects and control. N Engl J Med 313:491–498Google Scholar
  9. Friedman LM, Furberg CD, DeMets DL (1982) Fundamentals of clinical trials. John Wright PSG, Bristol, pp 69–87Google Scholar
  10. Hall SM, Tunstall CD, Ginsberg D, Benowitz NL, Jones RT (1987) Nicotine gum and behaverioural treatment: a placebocontrolled trial. J Consutt Clin Psychol 55:603–605Google Scholar
  11. Hjalmerson AIM (1984) Effect of nicotine chewing gum in smoking cessation. JAMA 252:2835–2838Google Scholar
  12. Hughes JR, Krahn D (1985) Blindness and the validity of the double-blind procedure. J Clin Psychopharm 5:138–140Google Scholar
  13. Jarvis ME, Russell MAH, Salooje Y (1980) Expired air carbon monoxid: a simple breath test of tobacco smoke intake. Br Med J 281:484–485Google Scholar
  14. Jarvis MJ, Raw M, Russel MAH, Feyerabend C (1982) Randomized controlled trial of nicotine chewing gum. Br Med J 285:537–540Google Scholar
  15. Jensen EJ, Schmidt E, Pedersen B, Dahl R (1991) Effect of nicotine, silver acetate and nicotine chewing gum in combination with group councelling on smoking cessation. Thorax (in press)Google Scholar
  16. Malcolm R (1986) Silver acetate gum as a smoking deterrent. Chest 89:107–111Google Scholar
  17. Murray E, Schneider NG (1984) Degree of addiction and effectiveness of nicotine gum therapy for smoking. Am J Psycho 141:790–791Google Scholar
  18. Raw M, Jarvis MJ, Feyerabend C, Russell MAH (1980) Comparison of nicotine chewing gum and psychological treatment for dependent smokers. Br Med J 281:481–482Google Scholar
  19. Schmidt F (1977) Raucherentwöhnung durch Anti-Raucher Kaugummi Dragees im Doppelblindversuch. Munch Med Wschr 119:1343–1344Google Scholar
  20. Schneider NG, Jarvik ME, Forsythe AB, Read LL, Elliot ML, Schweiger A (1983) Nicotine gum in smoking cessation: a placebo-controlled, double-blind trial. Addict Behav 8:253–261Google Scholar
  21. Tonnesen P, Fryd V, Hansen M, Helsted J, Gunnersen AB, For chammer H, Stockner M (1988) Effect of nicotine gum in combination with group counselling on the cessation of smoking. N Engl J Med 318:15–18Google Scholar
  22. West DV, Graham S, Swanson M, Wilkinson G (1977) Five year follow up of a smoking withdrawal clinic. Am J Public Health 30:123–131Google Scholar

Copyright information

© Springer-Verlag 1991

Authors and Affiliations

  • E. J. Jensen
    • 1
  • E. Schmidt
    • 1
  • B. Pedersen
    • 1
  • R. Dahl
    • 1
  1. 1.Department of Respiratory MedicineUniversity Hospital, NoerrebrogadeAarhus CDenmark

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