Psychopharmacology

, Volume 109, Issue 1–2, pp 92–98

Oral ethanol self-administration in rats is reduced by the administration of dopamine and glutamate receptor antagonists into the nucleus accumbens

  • Stefanie Rassnick
  • Luigi Pulvirenti
  • George F. Koob
Original Investigations

Abstract

The purpose of this study was to assess the role of endogenous dopamine and glutamate systems within the nucleus accumbens in modulating responses for oral ethanol reinforcements (10% w/v) in a free-choice operant task. Pretreatment with both systemic (100 µg/kg) and intra-nucleus accumbens microinjection of fluphenazine (2 and 4 µg), a dopamine receptor antagonist, significantly decreased responding for ethanol, without significantly affecting responses for water. Ethanol self-administration was also attenuated by microinjection into the nucleus accumbens of 2-amino-5-phosphopentanoic acid (AP-5, 3 and 6 µg), a competitive NMDA receptor antagonist. These results suggest that dopamine and glutamate neurotransmission in the nucleus accumbens may regulate ethanol self-administration and its reinforcing effects.

Key words

Ethanol self-administration Dopamine antagonist NMDA antagonist Nucleus accumbens 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Copyright information

© Springer-Verlag 1992

Authors and Affiliations

  • Stefanie Rassnick
    • 1
  • Luigi Pulvirenti
    • 1
  • George F. Koob
    • 1
  1. 1.Department of NeuropharmacologyThe Scripps Research InstituteLa JollaUSA

Personalised recommendations