Psychopharmacology

, Volume 106, Issue 3, pp 311–314

Serotonin but not norepinephrine-induced calcium mobilization of platelets is enhanced in affective disorders

  • Masahiko Mikuni
  • Ariyuki Kagaya
  • Kiyohisa Takahashi
  • Herbert Y. Meltzer
Original Investigations

DOI: 10.1007/BF02245410

Cite this article as:
Mikuni, M., Kagaya, A., Takahashi, K. et al. Psychopharmacology (1992) 106: 311. doi:10.1007/BF02245410

Abstract

Intracellular calcium concentrations ([Ca++]i) in blood platelets from 11 depressed patients and 11 healthy controls were investigated. The resting [Ca++]i of platelets from depressed patients was 69.4±2.9 nM while that from controls was 74.6±4.0 nM. Serotonin (5-HT), at a concentration of 10 µM, increased [Ca++]i by 129.2±3.9 nM in platelets from depressed patients, which was significantly greater than that found in platelets from control subjects (105.2±6.0 nM). Norepinephrine (NE) 100 µM increased [Ca++]i by 46.1±7.1 nM in platelets from depressed patients, and by 38.6±6.1 nM in platelets from controls, respectively. These results indicate that 5-HT2 receptor function in platelets of depressed patients is enhanced, and support the hypothesis of hypersensitivity of 5-HT2 receptors in affective disorders.

Key words

Depression Platelets Calcium Serotonin 

Copyright information

© Springer-Verlag 1992

Authors and Affiliations

  • Masahiko Mikuni
    • 1
  • Ariyuki Kagaya
    • 1
  • Kiyohisa Takahashi
    • 1
  • Herbert Y. Meltzer
    • 2
  1. 1.Division of Mental Disorder ResearchNational Institute of Neuroscience, National Center of Neurology and PsychiatryKodaira TokyoJapan
  2. 2.Laboratory of Biological PsychiatryCase Western Reserve University, School of MedicineClevelandUSA

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