Advertisement

Psychopharmacology

, Volume 108, Issue 1–2, pp 72–78 | Cite as

Delayed-non-match-to-sample performance in the radial arm maze: effects of dopaminergic and gabaergic agents

  • James J. Chrobak
  • T. Celeste Napier
Original Investigations

Abstract

Central dopaminergic transmission has been implicated in memory processes. The present experiments examined the effects of several direct acting dopaminergic agents on performance of a delayed-non-match-to-sample radial arm maze task. Preadministration of apomorphine (D1-D2 agonist; 0.25, 0.5, and 1.0 mg/kg), quinpirole (D2 agonist; 0.1 mg/kg), or SKF38393 (D1 agonist; 3 mg/kg) increased the latency of choices but did not affect any index of accuracy with a 1 h retention interval. Post-training administration of quinpirole (0.1, 0.2, 1.0, and 2.0 mg/kg), SKF38393 (0.3, 3.0, and 6.0 mg/kg), sulpiride (D2 antagonist; 3, 10, and 30 mg/kg), or SCH23390 (D1 antagonist; 0.01, 0.1, and 1.0 mg/kg) also did not affect accuracy, although quinpirole produced a dose-dependent increase in the latency of choices, assessed 10 h post-treatment. For comparison, pretraining and post-training administration of the benzodiazepine chlordiazepoxide (1, 3, 5 mg/kg) was also tested and produced dose-dependent impairments in mnemonic performance at either a 1 or 4 h retention interval. The effects of chlordiazepoxide are consistent with evidence indicating that GABAergic agents can influence memory processes. In contrast, the present findings indicate that (peripheral administration of dopaminergic agents IS) not sufficient to alter the mnemonic processes required for accurate performance of this DNMTS-RAM task.

Key words

Working/episodic memory Radial arm maze Non-match-to-sample task Dopamine Apomorphine Quinpirole SKF38393 Sulpiride SCH23390 Benzodiazepine Chlordiazepoxide 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Beatty WW, Shavalia DA (1980) Spatial memory in rats: time course of working memory and effect of anesthetics. Behav Neural Biol 28:454–462CrossRefPubMedGoogle Scholar
  2. Beatty WW, Rush JR (1983a) Retention deficit afterd-amphetamine treatment: memory defect or performance change? Behav Neural Biol 37:265–275CrossRefPubMedGoogle Scholar
  3. Beatty WW, Rush JR (1983b) Spatial working memory in rats: effect of monoaminergic antagonists. Pharmacol Biochem Behav 18:7–12CrossRefGoogle Scholar
  4. Beninger RJ (1983) The role of dopamine in locomotor activity and learning. Brain Res Rev 6:173–196CrossRefGoogle Scholar
  5. Beninger RJ (1989) Dissociating the effects of altered dopaminergic function on performance and learning. Brain Res Bull 23:365–371CrossRefPubMedGoogle Scholar
  6. Bjorklund A, Lindvall O (1984) Dopamine-containing systems in the CNS. In: Bjorklund A, Hokfelt T (eds) Handbook of chemical neuroanatomy, vol 2, classical transmitters in the CNS, Part I. Elsevier, AmsterdamGoogle Scholar
  7. Breese G, Napier TC, Mueller RA (1985) Dopamine agonist-induced locomotor activity in rats treated with 6-hydroxydopamine at differing ages: functional supersensitivity of D-1 dopamine receptors in neonatally lesioned rats. J Pharmacol Exp Ther 234:447–455PubMedGoogle Scholar
  8. Brioni JD, McGaugh JL (1988) Post-training administration of GABAergic antagonists enhances retention of aversively motivated tasks. Psychopharmacology 96:505–510CrossRefPubMedGoogle Scholar
  9. Brioni JD, Nagahara AH, McGaugh JL (1989) Involvement of the amygdala GABAergic system in the modulation of memory storage. Brain Res 487:105–112CrossRefPubMedGoogle Scholar
  10. Brozoski TJ, Brown RM, Rosvold HE, Goldman PS (1979) Cognitive deficit caused by regional depletion of dopamine in prefrontal cortex of rhesus monkey. Science 205:929–932PubMedGoogle Scholar
  11. Bubser M, Schmidt WJ (1990) 6-Hydroxydopamine lesion of the rat prefrontal cortex increases locomotor activity, impairs acquisition of delayed alternation tasks, but does not affect uninterrupted tasks in the radial maze. Behav Brain Res 37:157–168CrossRefPubMedGoogle Scholar
  12. Buresova O, Bures J (1982) Radial maze as a tool for assessing the effect of drugs on the working memory of rats. Psychopharmacology 77:268–271CrossRefPubMedGoogle Scholar
  13. Chrobak JJ, Napier TC (1991) Intraseptal administration of bicuculline produces working memory impairments in the rat. Behav Neural Biol 55:247–254CrossRefPubMedGoogle Scholar
  14. Chrobak JJ, Napier TC (1992) Antagonism of GABAergic transmission within the septum disrupts working/episodic memory in the rat. Neuroscience (in press)Google Scholar
  15. Chrobak JJ, Stackman R, Walsh TJ (1989) Intraseptal administration of muscimol produces dose-dependent memory impairments in the rat. Behav Neural Biol 52:357–369CrossRefPubMedGoogle Scholar
  16. Eckerman DA, Gordon WA, Edwards JD, MacPhail RC, Gage MI (1979) Effects of scopolamine, pentobarbital, and amphetamine on radial arm maze performance in the rat. Pharmacol Biochem Behav 12:595–602CrossRefGoogle Scholar
  17. Galey D, Durkin T, Sifakis G, Jaffard R (1984) Facilitation of spontaneous and learned spatial behaviours following 6-hydroxydopamine lesions of the lateral septum: a cholinergic hypothesis. Brain Res 340:171–174CrossRefGoogle Scholar
  18. Galey D, Toumane A, Durkin T, Jaffard (1989) In vivo modulation of septo-hippocampal cholinergic activity in mice: relationship with spatial reference and working memory performance. Behav Brain Res 32:163–172PubMedGoogle Scholar
  19. Gehlert DR, Wamsley JK (1985) Dopamine receptors in the rat brain: quantitative autoradiographic localization using [3H] sulpiride. Neurochem Int 7:717–723CrossRefGoogle Scholar
  20. Givens BS, Olton DS (1990) Cholinergic and GABAergic modulation of medial septal area: effect on working memory. Behav Neurosci 104:849–855CrossRefPubMedGoogle Scholar
  21. Harrell LE, Barlow S, Miller M, Haring JH, Davis JN (1984) Facilitated reversal learning of a spatial-memory task by medial septal injections of 6-hydroxydopamine. Exp Neurol 85:69–77CrossRefPubMedGoogle Scholar
  22. Heyman GM, Seiden LS (1985) A parametric description of amphetamine's effect on response rate: changes in reinforcement efficacy and response topography. Psychopharmacology 85:154–161CrossRefPubMedGoogle Scholar
  23. Hoffman DC, Beninger RJ (1989) Preferential stimulation of D1 or D2 receptors disrupts food-rewarded operant responding in rats. Pharmacol Biochem Behav 34:923–1925CrossRefPubMedGoogle Scholar
  24. Kesner RP, Bierley RA, Pebbles P (1981) Short-term memory: the role ofd-amphetamine. Pharmacol Biochem Behav 15:673–676CrossRefPubMedGoogle Scholar
  25. Le Moal M, Simon H (1991) Mesocorticolimbic dopaminergic network: functional and regulatory roles. Physiol Rev 71:155–234PubMedGoogle Scholar
  26. Levin ED (1988) Psychopharmacological effects in the radial-arm maze. Neurosci Biobehav Rev 12:169–175CrossRefPubMedGoogle Scholar
  27. Levin ED, Bowman RE (1986) Effects of the dopamine D2 receptor agonist, LY 171555, on radial-arm maze performance in rats. Pharmacol Biochem Behav 25:1117–1119CrossRefPubMedGoogle Scholar
  28. Levin ED, Rose JE (1991) Interactive effects of D1 and D2 agonists with scopolamine on radial-arm maze performance. Pharmacol Biochem Behav 38:243–246CrossRefPubMedGoogle Scholar
  29. MacPhail RC, Gollub LR (1975) Separating the effects of response rate and reinforcement frequency in the rate-dependent effects of amphetamine and scopolamine of the schedule-controlled performance of rats and pigeons. J Pharmacol Exp 194:332–342Google Scholar
  30. Maki WS (1985) Differential effect of electroconvulsive shock on concurrent spatial memories: old memories are impaired while new memories are spared. Behav Neural Biol 43:162–177CrossRefPubMedGoogle Scholar
  31. McGurk SR, Levin ED, Butcher LL (1989) Nicotinic-dopaminergic relationships and radial-arm maze performance in rats. Behav Neural Biol 52:78–86CrossRefPubMedGoogle Scholar
  32. Maslowski RJ, Napier TC (1991a) Dopamine D1 and D2 receptor agonists induce opposite changes in the firing rate of ventral pallidal neurons. Eur J Pharmacol 200:103–112CrossRefPubMedGoogle Scholar
  33. Miller R, Wickens JR, Beninger RJ (1990) Dopamine D-1 and D-2 receptors in relation to reward and performance: a case for the D-1 receptor as a primary site of therapeutic action of neuroleptic drugs. Prog Neurobiol 34:143–183CrossRefPubMedGoogle Scholar
  34. Murray AM, Waddington JL (1989) The induction of grooming and vacuous chewing by a series of selective D-1 dopamine receptor agonists: two directions of D-1:D-2 interactions. Eur J Pharmacol 160:377–384CrossRefPubMedGoogle Scholar
  35. Nabeshima T, Noda Y, Kameyama T (1988) GABAergic modulation of memory with regard to passive avoidance and conditioned suppression tasks in mice. Psychopharmacology 94:69–73Google Scholar
  36. Napier TC, Givens BS, Schulz DW, Bunney BS, Breese GR, Mailman RB (1986) SCH23390 effects on apomorphine-induced responses of nigral dopaminergic neurons. J Pharmacol Exp Ther 236:838–845PubMedGoogle Scholar
  37. Napier TC, Simson PE, Givens BS (1991) Dopamine electrophysiology of ventral pallidal/substantia innominata neurons: comparison with the dorsal globus pallidus. J Pharmacol Exp Ther 258:249–262PubMedGoogle Scholar
  38. Olton, DS, Samuelson, RJ (1976) Remembrances of places passed: spatial memory in rats. J Exp Psychol Animal Behav 2:97–116CrossRefGoogle Scholar
  39. Packard MG, White NM (1989) Memory facilitation produced by dopamine agonists: role of receptor subtype and mnemonic requirements. Pharmacol Biochem Behav 33:511–518CrossRefPubMedGoogle Scholar
  40. Quartermain D, Judge ME, Leo P (1988) Attenuation of forgetting by pharmacological stimulation of aminergic neurotransmitter systems. Pharmacol Biochem Behav 30:77–81CrossRefPubMedGoogle Scholar
  41. Richfield EK, Penney JB, Young AB (1989) Anatomical and affinity state comparisons between D1 and D2 receptors in the rat central nervous system. Neuroscience 3:767–777CrossRefGoogle Scholar
  42. Salamone JD (1988) Dopaminergic involvement in activational aspects of motivation: effects of haloperidol on schedule-induced activity, feeding and foraging in rats. Psychobiology 16:196–206Google Scholar
  43. Sara SJ (1985) Noradrenergic modulation of selective attention: its role in memory retrieval. Ann NY Acad Sci 444:178–193PubMedGoogle Scholar
  44. Sawaguchi T, Goldman-Rakic PS (1991) D1 dopamine receptors in prefrontal cortex: involvement in working memory. Science 251:947–950PubMedGoogle Scholar
  45. Simon H, Taghzouti K, Le Moal M (1986) Deficits in spatial-memory tasks following lesions of septal dopaminergic terminals in the rat. Behav Brain Res 19:7–16CrossRefPubMedGoogle Scholar
  46. Stackman R, Walsh TJ (1992) Chlordiazepoxide-induced working memory impairment: site specificity and reversal with flumazenil. Behav Neural Biol (in press)Google Scholar
  47. Whishaw IQ, Dunnett SB (1985) Dopamine depletion, stimulation or blockade in the rat disrupts spatial navigation and locomotion dependent upon beacon or distal cues. Behav Brain Res 18:11–29CrossRefPubMedGoogle Scholar
  48. Williams JEG, Woolverton WL (1990) The D2 agonist quinpirole potentiates the discriminative stimulus effects of the D1 agonist SKF38393. Pharmacol Biochem Behav 37:289–293CrossRefPubMedGoogle Scholar
  49. Willner G, Sampson D, Phillips G, Muscat R (1990) A matching law analysis of the effects of dopamine receptor antagonists. Psychopharmacology 101:560–567Google Scholar

Copyright information

© Springer-Verlag 1992

Authors and Affiliations

  • James J. Chrobak
    • 1
  • T. Celeste Napier
    • 1
  1. 1.Department of Pharmacology and Experimental Therapeutics, Stritch School of MedicineLoyola University ChicagoMaywoodUSA

Personalised recommendations