, Volume 107, Issue 2–3, pp 425–430 | Cite as

Abolition of latent inhibition by a single 5 mg dose ofd-amphetamine in man

  • N. S. Gray
  • A. D. Pickering
  • D. R. Hemsley
  • S. Dawling
  • J. A. Gray
Original Investigations


The performance of healthy volunteer subjects on an auditory latent inhibition (LI) paradigm was assessed following administration of a single oral dose ofd-amphetamine or placebo. It was predicted that a low (5 mg), but not a high (10 mg), dose ofd-amphetamine would disrupt LI. The prediction was supported with left ear presentation of the preexposed stimulus only. When the preexposed stimulus was presented to the right ear the predicted pattern of findings was not obtained. It is concluded that the dopaminergic system is involved in the mediation of LI in man and it is speculated that the interaction between amphetamine dose and ear of presentation of the preexposed stimulus may reflect normally occurring dopaminergic hemisphere asymmetry.

Key words

Latent inhibition d-Amphetamine Schizophrenia Attention Man Lateralisation of function 


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Copyright information

© Springer-Verlag 1992

Authors and Affiliations

  • N. S. Gray
    • 1
  • A. D. Pickering
    • 2
  • D. R. Hemsley
    • 1
  • S. Dawling
    • 3
  • J. A. Gray
    • 1
  1. 1.Department of PsychologyInstitute of PsychiatryLondonUK
  2. 2.Department of PsychologySt. George's Hospital Medical SchoolLondonUK
  3. 3.National Poisons UnitGuy's and Lewisham TrustLondonUK

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