Psychopharmacology

, Volume 108, Issue 3, pp 371–379

Differential effects of diazepam and lorazepam on repetition priming in healthy volunteers

  • François Sellal
  • Jean-Marie Danion
  • Françoise Kauffmann-Muller
  • Danielle Grangé
  • Jean-Louis Imbs
  • Martial Van Der Linden
  • Léonard Singer
Original Investigations

Abstract

The effects of two benzodiazepines, diazepam (15 or 20 mg orally) and lorazepam (1.75 or 2.5 mg orally), and a placebo on explicit memory, lexical priming and perceptual priming were assessed using a freerecall, a word-completion and a picture-completion test. The picture-completion test included two different study conditions intended to manipulate the magnitude of the priming effect. Sixty healthy volunteers took part in this double-blind study. Free-recall performances were altered by both drugs. Lorazepam impaired word-completion and picture-completion performance, whereas diazepam only exhibited a deleterious effect on the more sensitive of the two measures of the picture-completion test. These results indicate that the two benzodiazepines have differential amnestic effects. It is suggested that these differential effects could be accounted for by a different cortical distribution of the two benzodiazepines.

Key words

Benzodiazepines Diazepam Human Lorazepam Memory Repetition priming 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Copyright information

© Springer-Verlag 1992

Authors and Affiliations

  • François Sellal
    • 1
  • Jean-Marie Danion
    • 2
  • Françoise Kauffmann-Muller
    • 2
  • Danielle Grangé
    • 3
  • Jean-Louis Imbs
    • 4
  • Martial Van Der Linden
    • 5
  • Léonard Singer
    • 2
  1. 1.Clinique Neurologique, Service de Neurologie IHôpitaux UniversitairesStrasbourg CedexFrance
  2. 2.Departement de PsychiatrieHôpitaux UniversitairesStrasbourg CedexFrance
  3. 3.Centre de Calcul, C.N.R.S.StrasbourgFrance
  4. 4.Institut de Pharmacologie, Unité de Pharmacologie CliniqueFaculté de MédecineStrasbourgFrance
  5. 5.Unité de Neuropsychologie CognitiveUniversité de Louvain, Faculté de PsychologieLouvain La NeuveBelgium

Personalised recommendations