Psychopharmacology

, Volume 114, Issue 4, pp 672–674

The putative anti-addictive drug ibogaine is a competitive inhibitor of [3H]MK-801 binding to the NMDA receptor complex

  • Piotr Popik
  • Richard T. Layer
  • Phil Skolnick
Rapid Communication

DOI: 10.1007/BF02245000

Cite this article as:
Popik, P., Layer, R.T. & Skolnick, P. Psychopharmacology (1994) 114: 672. doi:10.1007/BF02245000

Abstract

Ibogaine is a putative anti-addictive drug with potential efficacy for the treatment of opiate, stimulant, and alcohol abuse. We now report ibogaine is a competitive inhibitor (Ki, 1.01±0.1 µM) of [3H]MK-801 binding toN-methyl-D-aspartate (NMDA) receptor coupled cation channels. Since MK-801 can attenuate the development of tolerance to morphine and alcohol as well as sensitization to stimulants in preclinical studies, the reported ability of ibogaine to modify drug-seeking behavior in man may be attributable to a blockade of NMDA receptor coupled cation channels.

Key words

MK-801 (dizocilpine) Ibogaine NMDA receptors Drug abuse 

Copyright information

© Springer-Verlag 1994

Authors and Affiliations

  • Piotr Popik
    • 1
  • Richard T. Layer
    • 1
  • Phil Skolnick
    • 1
  1. 1.Laboratory of NeuroscienceNIDDK, National Institutes of HealthBethesdaUSA

Personalised recommendations