Psychopharmacology

, Volume 111, Issue 3, pp 376–382 | Cite as

Influence of histamine depletion on learning and memory recollection in rats

  • Chiaki Kamei
  • Yasushi Okumura
  • Kenji Tasaka
Original Investigations

Abstract

To clarify the role of endogenous histamine in learning and memory, the effect of α-fluoromethylhistidine on active avoidance response in rats was studied. α-Fluoromethylhistidine (20–100 mg/kg or 10–50 µg) significantly (P<0.05 orP<0.01) prolonged the response latency in active avoidance response when administered by either intraperitoneal or intracerebroventricular injection. These effects were dose-related and long lasting. A prolongation of the response latency induced by an intraperitoneal injection of α-fluoromethylhistidine (100 mg/kg) was antagonized by intracerebroventricular injection of histamine (10 and 20 ng) in a dose-dependent manner. In addition, the acquisition of this response was retarded by a consecutive intracerebroventricular injection of α-fluoromethylhistidine (50 µg), whereas histamine (100 ng) facilitated the response acquisition when administered by the same route. Both intraperitoneal (100 mg/kg) and intracerebroventricular injection of α-fluoromethylhistidine (50 µg) significantly (P<0.05 orP<0.01) decreased the brain histamine content, especially in the hippocampus and hypothalamus. When α-fluoromethylhistidine (50 µg) was injected intracerebroventricularly, there is a high correlation between a prolongation of the response latency and a decrease in histamine content of these brain areas. Based on these findings, it was concluded that an intimate relation may exist between a prolongation of response latency in the active avoidance response and a decrease in the brain histamine content; endogenous histamine may play an important role in learning and memory recollection in rats.

Key words

Histamine α-Fluoromethylhistidine Active avoidance response Acquisition memory Brain histamine content 

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References

  1. Alvarez EO, Banzán AM (1986) Histamine in dorsal and ventral hippocampus II. Effects of H1 and H2 histamine antagonists on exploratory behavior in male rats. Physiol Behav 37:39–45CrossRefPubMedGoogle Scholar
  2. Asdourian D, Dark JG, Chiodo L, Papich PS (1977) Active avoidance in rats with unilateral hypothalamic and optic nerve lesions. Physiol Behav 19:209–211CrossRefPubMedGoogle Scholar
  3. Cacabelos R, Alvarez XA (1991) Histidine decarboxylase inhibition induced by α-fluoromethylhistidine provokes learning-related hypokinetic activity. Agents Actions 33:131–134CrossRefPubMedGoogle Scholar
  4. de Groot J (1959) The rat forebrain in stereotaxic coordinates. Verh K Ned Acad Wed Natuurkund 52:1–40Google Scholar
  5. Duggan DE, Hooke KF, Maycock AL (1984) Inhibition of histamine synthesis in vitro and in vivo by S-α-fluoromethylhistidine. Biochem Pharmacol 33:4003–4009CrossRefPubMedGoogle Scholar
  6. Garbarg M, Barbin G, Rodergas E, Schwartz JC (1980) Inhibition of histamine synthesis in brain by α-fluoromethylhistidine, a new irreversible inhibitor: In vitro and in vivo studies. J Neurochem 35:1045–1052PubMedGoogle Scholar
  7. Glowinski J, Iversen LL (1966) Regional studies of catecholamines in the rat brain I. The disposition of [3H]norepinephrine, [3H]dopamine and [3H]dopa in various regions of the brain. J Neurochem 13:655–669PubMedGoogle Scholar
  8. Grossman SP (1970) Avoidance behavior and aggression in rats with transections of the lateral connections of the medial or lateral hypothalamus. Physiol Behav 5:1103–1108CrossRefPubMedGoogle Scholar
  9. Hall CS (1934) Drive and emotionality: factors associated with adjustment in the rat. J Comp Psychol 17:89–108Google Scholar
  10. Irwin S (1968) Comprehensive observational assessment: Ia. A systematic, quantitative procedure for assessing the behavioral and physiological state of the mouse. Psychopharmacology 13:222–257CrossRefGoogle Scholar
  11. Kamei C, Tasaka K (1991) Participation of histamine in the stepthrough active avoidance response and its inhibition by H1-blockers. Jpn J Pharmacol 57:473–482PubMedGoogle Scholar
  12. Kamei C, Tasaka K (1992) Effect of intracerebroventricular injection of histamine on memory impairment induced by hippocampal lesions in rats. Jpn J Pharmacol 58 [Suppl. 1]:55pGoogle Scholar
  13. Kamei C, Tasaka K (1993) Effect of histamine on memory retrieval in old rats. Biol Pharm Bull 16:128–132PubMedGoogle Scholar
  14. Kamei C, Tsujimoto S, Tasaka K (1990a) Effects of cholinergic drugs and cerebral metabolic activators on memory impairment in old rats. J Pharmacobiodyn 13:772–777PubMedGoogle Scholar
  15. Kamei C, Chung YH, Tasaka K (1990b) Influence of certain H1-blockers on the step-through active avoidance response in rats. Psychopharmacology 102:312–318CrossRefPubMedGoogle Scholar
  16. Kollonitsch J, Patchett AA, Marburg S, Maycock AL, Perkins LM, Doldouras GA, Duggan DE, Aster SD (1978) Selective inhibitors of biosynthesis of aminergic neurotransmitters. Nature 274:906–908Google Scholar
  17. Maeyama K, Watanabe T, Yamatodani A, Taguchi Y, Kambe H, Wada H (1983) Effect of α-fluoromethylhistidine on the histamine content of the brain of W/Wv mice devoid of mast cells: turnover of brain histamine. J Neurochem 41:128–134PubMedGoogle Scholar
  18. McNew JJ, Thompson R (1966) Role of the limbic system in active and passive avoidance conditioning in the rat. J Comp Physiol Psychol 61:173–180PubMedGoogle Scholar
  19. Oishi R, Nishibori M, Itoh Y, Saeki K, Fukuda T, Araki Y (1988) Histamine turnover in the brain of morphine-dependent mice. Naunyn-Schmiedeberg's Arch Pharmacol 337:58–63CrossRefGoogle Scholar
  20. Oishi R, Baba M, Nishibori M, Itoh Y, Saeki K (1989) Involvement of central histaminergic and cholinergic systems in the morphine-induced increase in blood-brain barrier permeability to sodium fluorescein in mice. Naunyn-Schmiedberg's Arch Pharmacol 339:159–165CrossRefGoogle Scholar
  21. Onodera K, Yamatodani A, Watanabe T (1992) Effects of α-fluoromethylhistidine on locomotor activity, brain histamine and catecholamine contents in rats. Methods Find Exp Clin Pharmacol 14:97–105PubMedGoogle Scholar
  22. Papsdorf JD, Woodruff M (1970) Effects of bilateral hippocampectomy on the rabbit's acquisition of shuttle-box and passive-avoidance responses. J Comp Physiol Psychol 73:486–489PubMedGoogle Scholar
  23. Sakai N, Onodera K, Maeyama K, Yanai K, Watanabe T (1992) Effects of (S)-α-fluoromethylhistidine and metoprine on locomotor activity and brain histamine content in mice. Life Sci 51:397–405CrossRefPubMedGoogle Scholar
  24. Sakurai E, Niwa H, Yamasaki S, Maeyama K, Watanabe T (1990) The disposition of a histidine decarboxylase inhibitor (S)-α-fluoromethylhistidine in rats. J Pharm Pharmacol 42:857–860PubMedGoogle Scholar
  25. Tasaka K, Chung YH, Sawada K, Mio M (1989) Excitatory effect of histamine on the arousal system and its inhibition by H1 blockers. Brain Res Bull 22:271–275CrossRefPubMedGoogle Scholar
  26. Yamatodani Y, Watanabe T (1991) Studies with α-fluoromethylhistidine as a probe. In: Watanabe T, Wada H (eds) Histaminergic neurons, morphology and function. CRC Press, Boston, pp 231–240Google Scholar

Copyright information

© Springer-Verlag 1993

Authors and Affiliations

  • Chiaki Kamei
    • 1
  • Yasushi Okumura
    • 1
  • Kenji Tasaka
    • 1
  1. 1.Department of Pharmacology, Faculty of Pharmaceutical SciencesOkayama UniversityOkayamaJapan

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