Psychopharmacology

, Volume 112, Issue 4, pp 461–466

Ritanserin attenuates anorectic, endocrine and thermic responses tod-fenfluramine in human volunteers

  • E. M. Goodall
  • P. J. Cowen
  • M. Franklin
  • T. Silverstone
Original Investigations

Abstract

This study investigated the role of the 5-HT2/1C receptor antagonist ritanserin ond-fenfluramine (d-FF) induced changes in food intake, prolactin (PRL) secretion and oral temperature in 12 healthy male volunteers. The study was double blind and placebo controlled. Food intake was measured using an automated food dispenser.d-FF (30 mg) significantly reduced fat intake. While ritanserin (5 mg) had no effect when given alone it abolished thed-FF induced reduction in fat intake. In addition, ritanserin abolished thed-FF induced rise in PRL and oral temperature. The results suggest that 5-HT2 or 5-HT1C receptors mediate the effects ofd-fenfluramine on appetite, prolactin secretion and temperature in humans.

Key words

d-Fenfluramine Ritanserin Food intake Prolactin Body temperature Human volunteers 

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Copyright information

© Springer-Verlag 1993

Authors and Affiliations

  • E. M. Goodall
    • 1
  • P. J. Cowen
    • 2
  • M. Franklin
    • 2
  • T. Silverstone
    • 1
  1. 1.Department of Psychological MedicineMedical College of St. Bartholomew's HospitalLondonUK
  2. 2.MRC Unit of Clinical Pharmacology and University Department of PsychiatryLittlemore HospitalOxfordUK

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