Eight patients suffering from the alcoholic Korsakoff syndrome (AKS) were entered in a double-blind cross-over trial of fluvoxamine 200 mg per day for 4 weeks versus matched placebo for 4 weeks. At the end of each phase, patients were assessed using a detailed neuropsychological test battery. Verbal fluency performance was significantly impaired following fluvoxamine treatment. No significant differences emerged on any of the other cognitive test measures when fluvoxamine was compared with placebo. However, two of the patients developed a major depressive episode while receiving fluvoxamine.
This is a preview of subscription content, log in to check access.
Buy single article
Instant access to the full article PDF.
Price includes VAT for USA
Subscribe to journal
Immediate online access to all issues from 2019. Subscription will auto renew annually.
This is the net price. Taxes to be calculated in checkout.
Baddeley AD (1976) The psychology of memory. Basic Books, New York
Benton AL, Hamsher K (1978) Multilingual aphasia examination manual — revised. University of Iowa, Iowa City
Bowden SC (1990) Separating cognitive impairment in neurologically asymptomatic alcoholism from Wernicke-Korsakoff syndrome: is the neuropsychological distinction justified? Psychol Bull 3: 355–366
Broadbent DE, Cooper PF, FitzGerald P, Parkes KR (1982) The cognitive failures questionnaire (CFQ) and its correlates. Br J Clin Psychol 21: 1–16
Kolb B, Whishaw IQ (1990) Fundamentals of human neuropsychology, 3rd Edn. Freeman & Co., New York
Lezak M (1983) Neuropsychological assessment, 2nd Edn. Oxford University Press, Oxford
Lishman WA (1987) Organic psychiatry. The psychological consequences of cerebral disorder, 2nd Edn. Blackwell, Oxford
Mair RG, McEntee WJ (1986) Cognitive enhancement in Korsakoff's psychosis by clonidine: a comparison with L-Dopa and ephedrine. Psychopharmacology 88: 374–380
Martin PR, Adinoff B, Eckardt MJ, Stapleton JM, Bone GAH, Rubinow DR, Lane EA, Linnoila M (1989) Effective pharmacotherapy of alcoholic amnestic disorder with fluvoxamine. Arch Gen Psychiatry 46: 617–621
McEntee WJ, Mair RG (1978) Memory impairment in Korsakoff's psychosis: a correlation with brain noradrenergic activity. Science 202: 905–907
McEntee WJ, Mair RG (1980) Memory enhancement in Korsakoff's psychosis by clonidine: further evidence for a noradrenergic deficit. Ann Neurol 7: 466–470
McEntee WJ, Mair RG (1990) The Korsakoff syndrome: a neurochemical perspective. Trends Neurosci 13: 340–344
Milner B (1964) Some effects of frontal lobectomy in man. In: Warren JM, Akert K (eds) The frontal granular cortex and behaviour. McGraw Hill, New York
O'Carroll RE, Moffoot A, Ebmeier KP, Murray C, Goodwin GM (1993) Korsakoff's syndrome, cognition and clonidine. Psychol Med 23: 341–347
Office of Population Censuses and Surveys (OPCS) (1980) Classification of Occupations. HMSO, London
Roth M, Tym E, Mountjoy CQ, Huppert FA, Hendrie H, Verma S, Goddard R (1986) CAMDEX: a standardised instrument for the diagnosis of mental disorder in the elderly with special reference to the early detection of dementia. Br J Psychiatry 149: 698–709
Shallice T, Evans M (1978) The involvement of the frontal lobes in cognitive estimation. Cortex 14: 294–303
Shoqeirat MA, Mayes A, MacDonald C, Meudell P, Pickering A (1990) Performance on tests sensitive to frontal lobe lesions by patients with organic amnesia: Leng & Parkin revisited. Br J Clin Psychol 29: 401–408
Victor M, Adams RD, Collins GH (1989) The Wernicke-Korsakoff syndrome and related neurological disorders due to alcoholism and malnutrition. F.A. Davis, Philadelphia
Wechsler D (1945) A standardised memory scale for clinical use. J Psychol 19: 87–95
Wechsler D (1987) Wechsler memory scale — revised. The psychological corporation. Harcourt Brace Jovanovich, New York
Weingarter H, Rudorfer MV, Buchsbaum MS, Linnoila M (1983) Effects of serotonin on memory impairments produced by ethanol. Science 221: 472–474
Wilson B, Cockburn J, Baddeley AD (1985) Rivermead behavioural memory test. Thames Valley Test, Titchfield, Fareham
About this article
Cite this article
O'Carroll, R.E., Moffoot, A.P.R., Ebmeier, K.P. et al. Effects of fluvoxamine treatment on cognitive functioning in the alcoholic Korsakoff syndrome. Psychopharmacology 116, 85–88 (1994). https://doi.org/10.1007/BF02244875