Lack of effect of high-dose cocaine on monoamine uptake sites in rat brain measured by quantitative autoradiography
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There have been a number of claims that high-dose administration of cocaine to rats leads to neurotoxic effects on dopamine neurons. In this study possible neurotoxic effects on monoamine neurons were examined by measuring the effects of cocaine (35 mg/kg daily for 10 days) on the binding of radioligands to uptake sites for dopamine, serotonin and norepinephrine using quatitative autoradiography. No effects of cocaine on any of the binding sites were observed and therefore, it is concluded that cocaine, unlike amphetamine derivatives which have similar pharmacologic properties, does not produce neurotoxic effects on monoamine neurons.
Key wordsNeurotoxicity Cocaine Dopamine Serotonin Norepinephrine Uptake sites
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- Akimoto K, Hamamura T, Kazahaya Y, Akiyama K, Otsuki S (1990) Enhanced extracellular dopamine level may be the fundamental neuropharmacological basis of cross-behavioral sensitization between methamphetamine and cocaine — an in vivo dialysis study in freely moving rats. Brain Res 507:344–346CrossRefPubMedGoogle Scholar
- Brunswick DJ, Tejani-Butt SM, Hauptmann M (1990) Effects of high-dose methamphetamine (MA) on norepinephrine (NE) and dopamine (DA) uptake sites in rat brain measured by quantitative autoradiography. Soc Neurosci Abstr 16:1111Google Scholar
- De Souza EB, Battaglia G (1990) Effects of MDMA and MDA on brain serotonin neurons: evidence from neurochemical and autoradiographic studies. In: Asghar K, De Souza E (eds) Pharmacology and toxicology of amphetamine and related designer drugs. NIDA Research Monograph 94, pp 270–305Google Scholar
- Feingold E, Seshadri SB, Tretiak O (1986) Hardware and software design considerations in engineering an image processing workstation: autoradiographic analysis with DUMAS and the BRAIN autoradiographic analysis software package. In: McEachron DL (ed) Experimental biology and medicine, vol 11. Functional mapping in biology and medicine. Karger, Basel, pp 175–203Google Scholar
- Paxinos G, Watson C (1986) The rat brain in stereotaxic coordinates. Academic Press, New YorkGoogle Scholar
- Seiden LS, Ricaurte GA (1987) Neurotoxicity of methamphetamine and related drugs. In: Meltzer HY (ed) Psychopharmacology: the third generation of progress. Raven Press, New York, pp 359–366Google Scholar
- Tejani-Butt SM, Bauer M, Brunswick DJ, Frazer A (1990a) Binding of [3H]-nisoxetine to rat brain: a new radioligand for norepinephrine uptake sites. Soc Neurosci Abstr 16:524Google Scholar