Psychopharmacology

, Volume 100, Issue 3, pp 355–360

Bromocriptine self-administration and bromocriptine-reinstatement of cocaine-trained and heroin-trained lever pressing in rats

  • R. A. Wise
  • A. Murray
  • M. A. Bozarth
Original Investigations
  • 99 Downloads

Abstract

Rats were trained to lever press for intravenous cocaine (1.0 mg/kg/injection) and then switched to bromocriptine (0.3, 1.0, or 3.0 mg/kg/injection) on a FR-1 reinforcement schedule. Bromocriptine sustained responding at all three doses; hourly drug intake increased linearly with log-dose. In a second experiment, animals were trained to respond for cocaine (1.0 mg/kg/injection) or heroin (0.1 mg/kg/injection) reinforcement; drug was available for the first 2 h of each daily session; saline was substituted for cocaine or heroin for 5 subsequent hours. One hour into each saline substitution session, an intravenous injection of saline or bromocriptine (0.0, 0.5, 1.0, or 2.0 mg/kg) was given. Bromocriptine reinstated both cocaine-trained and herointrained lever pressing; under these conditions, the drug was most effective in the heroin-trained animals. Reinforcing doses of clonidine (0.0625 and 0.125 mg/kg), methohexital, and nicotine (0.05 and 0.1 mg/kg), and a sub-intoxicating dose of ethanol (2 g/kg) failed to reinstate cocaine-trained responding. These data indicate that bromocriptine has cocaine-like and heroin-like stimulus and reinforcing effects.

Key words

Bromocriptine Cocaine Heroin Self-administration Reinforcement Reinstatement 

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Copyright information

© Springer-Verlag 1990

Authors and Affiliations

  • R. A. Wise
    • 1
  • A. Murray
    • 1
  • M. A. Bozarth
    • 2
  1. 1.Center for Studies in Behavioral Neurobiology, Department of PsychologyConcordia UniversityMontrealCanada
  2. 2.Department of PsychologyState University of New YorkBuffaloUSA

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