The aim of the study was to determine the effect of repeated oral administration of ondansetron, a 5-hydroxytryptamine type 3 (5-HT3) receptor antagonist, on psychomotor performance. The study was of a randomised, double-blind, four-way, cross-over design in 12 healthy subjects, with 1 mg and 8 mg ondansetron, placebo and 2 mg lorazepam evaluated. Each subject received five administrations per treatment period. Ondansetron, 1 mg and 8 mg, and placebo were given as twice daily dosing for 2 1/2 days. Lorazepam was administered as a 2 mg single oral dose which was taken as the fifth administration; placebo was given for the remaining four doses. Within each treatment period, subjects underwent a baseline (pre-dose) assessment of psychomotor performance using four commonly used and validated psychomotor tests, and were then re-assessed after the fifth and final dose over a 7-h, post-dose period. Following dosing with lorazepam, statistically significant changes were seen in five of the six test variables compared with placebo. Ondansetron, at both the 1 mg and the 8 mg doses, did not produce a statistically significant effect on any measure of psychomotor performance compared with placebo.
This is a preview of subscription content, log in to check access.
Buy single article
Instant access to the full article PDF.
Price includes VAT for USA
Subscribe to journal
Immediate online access to all issues from 2019. Subscription will auto renew annually.
This is the net price. Taxes to be calculated in checkout.
Blackwell CP, Harding SM (1989) The clinical pharmacology of ondansetron. Eur J Cancer Clin Oncol 25 [Suppl 1]:S21-S24
Butler A, Hill JM, Ireland SJ, Jordan CC, Tyers MB (1988) Pharmacological properties of GR38032F, a novel antagonist at 5-HT3 receptors. Br J Pharmacol 94:397–412
Costall B, Domeney AM, Kelly ME, Naylor RJ, Tyers MB (1987) The antipsychotic potential of GR38032F, a selective antagonist of 5-HT3 receptors in the central nervous system. Br J Pharmacol 90:89P
Hindmarch I (1980) Psychomotor function and psychoactive drugs. Br J Clin Pharmacol 10:189–209
Hindmarch I (1982) Critical flicker fusion frequency (CFFF): the effects of psychotropic compounds. Pharmacopsychiatria 15 [Suppl 1]:44–48
Hindmarch I, Ott H (1988) Psychopharmacology series 6. Benzodiazepine receptor ligands, memory and information processing, 1st edn. Springer, Berlin Heidelberg New York
Hindmarch I, Parrott AC (1978a) Clobazam, a 1,5-benzodiazepine derivative: effects upon human psychomotor performance under different levels of task reinforcement. Arch Int Pharmacodyn Ther 232 [Suppl 2]:261–268
Hindmarch I, Parrott AC (1978b) The effects of sub-chronic administration of three dose levels of 1,5-benzodiazepine, clobazam, on subjective aspects of sleep and psychomotor performance the morning after night-time medication. Arzneimittelforschung 28 [Suppl 2]:2169–2172
Hindmarch I, Subhan Z (1983) The effects of midazolam in conjunction with alcohol on sleep, psychomotor performance and car driving ability. Int J Clin Pharmacol Res 5 [Suppl 5]:323–329
Hindmarch I, Subhan Z, Stoker MJ (1983) The effects of zimeldine and amitriptyline on car driving and psychomotor performance. Acta Psychiatrica Scandinavica 68:141–146
Jones BJ, Oakley NB, Tyers MB (1987) The anxiolytic activity of GR38032F, a 5-HT3 receptor antagonist in the rat and cynomolgus monkey. Br J Pharmacol 90:88P
Marty M (1989) Ondansetron in the prophylaxis of acute cisplatin-induced nausea and vomiting. Eur J Cancer Clin Oncol 25 [Suppl 1]:S41-S45
Matthews JNF, Altman DG, Campbell MJ, Royston P (1990) The analysis of serial measurements in medical research. Br Med J 300:230–235
Preston GC, Broks P, Traub M, Poppleton P, Stahl SM (1988) Effects of lorazepam on memory, attention and sedation in man. Psychopharmacology 95:208–215
Priestman TJ (1989) Clinical studies with ondansetron in the control of radiation-induced emesis. Eur J Cancer Clin Oncol 25 [Suppl 1]:S29–S33
Schmoll H-J (1989) The role of ondansetron in the treatment of emesis induced by non-cisplatin-containing chemotherapy regimens. Eur J Cancer Clin Oncol 25 [Suppl 1]:S35-S39
Sternberg S (1966) High speed scanning in human memory. Science 153:652–654
Sternberg S (1975) Memory scanning: new findings and current controversies. QJ Exp Psychol 27:1–32
About this article
Cite this article
Hall, S.T., Ceuppens, P.R. A study to evaluate the effect of ondansetron on psychomotor performance after repeated oral dosing in healthy subjects. Psychopharmacology 104, 86–90 (1991). https://doi.org/10.1007/BF02244559
- Psychomotor performance
- Healthy subjects