, Volume 100, Issue 2, pp 195–200

Effects of dopaminergic agents on alcohol consumption by rats in a limited access paradigm

  • M. A. Linseman
Original Investigations


The effects of several dopaminergic drugs on alcohol consumption were studied in free-feeding rats using a limited access paradigm. Ascending doses of amphetamine (0.1, 0.3 and 1.0 mg/kg), haloperidol (0.1, 0.3 and 1.0 mg/kg), SKF 38 393 (a D1 receptor agonist − 0.3, 1.0 and 3.0 mg/kg), quinpirole (LY 171 555, a D2 receptor agonist − 0.03, 0.1 and 0.3 mg/kg), SCH 23 390 (a D1 receptor blocker, 0.003, 0.01, 0.03 and 0.1 mg/kg) and spiperone (a D2 receptor blocker, 0.003, 0.01, 0.03 and 0.1 mg/kg) were administered IP to rats approximately 30 min prior to their 1-h per day access to alcohol. Each dose was administered for 5 successive days, and the effects of the drugs were compared to those of respective saline or 0.4% lactic acid solution controls. Although there was an overall significant dose effect of amphetamine on alcohol consumption, no single dose altered alcohol consumption significantly from baseline. SKF 38 393 specifically decreased alcohol consumption at the highest dose of 3 mg/kg. Quinpirole significantly increased water consumption at the highest dose but had no effect on alcohol consumption. The antagonist haloperidol decreased alcohol consumption but only at doses that also reduced water consumption. The specific antagonists SCH 23 390 and spiperone decreased water consumption at the highest doses tested without modifying alcohol consumption. Taken together, these data suggest that dopamine does not play as critical a role in mediating the reinforcing effects of alcohol (insofar as they are reflected by alcohol consumption) as it does in relation to other psychoactive drugs, particularly the psychomotor stimulants.

Key words

Alcohol Ethanol Drinking Self-administration Dopamine Amphetamine Haloperidol SKF 38 393 Quinpirole SCH 23 390 Spiperone 


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  1. Anokhina IP (1984) Dopamine receptor agonists in the treatment of alcoholism. In: Edwards G, Littleton J (eds) Pharmacological treatments for alcoholism. Croom Helm, London, pp 145–151Google Scholar
  2. Brown ZW, Amit Z (1977) The effects of selective catecholamine depletions by 6-hydroxydopamine on ethanol preference in rats. Neurosci Lett 5:333–336CrossRefGoogle Scholar
  3. Brown ZW, Gill K, Abitbol M, Amit Z (1982) Lack of effect of dopamine receptor blockade on voluntary ethanol consumption in rats. Behav Neur Biol 36:291–294CrossRefGoogle Scholar
  4. Clark D, White FJ (1987) Review: D1 dopamine receptor — the search for a function: a critical evaluation of the D1/D2 dopamine receptor classification and its functional implications. Synapse 1:347–388CrossRefPubMedGoogle Scholar
  5. Daoust M, Saligaut C, Chadelaud M, Chretien P, Moore N, Boismare F (1984) Attenuation by antidepressant drugs of alcohol intake in rats. Alcohol 1:379–383CrossRefPubMedGoogle Scholar
  6. Daoust M, Moore N, Saligaut C, Lhuintre JP, Chretien P, Boismare F (1986) Striatal dopamine does not appear involved in the voluntary intake of ethanol by rats. Alcohol 3:15–17CrossRefPubMedGoogle Scholar
  7. Davis WM, Smith SG, Werner TE (1978) Noradrenergic role in the self-administration of ethanol. Pharmacol Biochem Behav 9:369–374CrossRefPubMedGoogle Scholar
  8. Di Chiara G, Imperato A (1985) Ethanol preferentially stimulates dopamine release in the nucleus accumbens. Eur J Pharmacol 115:131–132CrossRefPubMedGoogle Scholar
  9. Feldman HS (1983) Apomorphine in the treatment of alcohol addiction: neuro-physiological and therapeutic aspects. Psychiatr J Univ Ottawa 8:30–37Google Scholar
  10. Froehlich JC, Harts J, Lumeng L, Li T-K (1987) Naloxone attenuation of voluntary alcohol consumption. Alcohol Alcoholism Suppl 1:333–337Google Scholar
  11. Fuchs V, Burbes E, Coper H (1984) The influence of haloperidol and aminooxyacetic acid on etonitazene, alcohol, diazepam and barbital consumption. Drug Alcohol Depend 14:179–186CrossRefPubMedGoogle Scholar
  12. Gessa GL, Muntoni F, Collu M, Vargiu L, Mereu G (1985) Low doses of ethanol activate dopaminergic neurons in the ventral tegmental area. Brain Res 348:201–203CrossRefPubMedGoogle Scholar
  13. Gilbert DB, Cooper SJ (1985) Analysis of dopamine D1 and D2 receptor involvement ind- andl-amphetamine-induced anorexia in rats. Brain Res Bull 15:385–389CrossRefPubMedGoogle Scholar
  14. Gill K, Amit Z (1987) Effects of serotonin uptake blockade on food, water, and ethanol consumption in rats. Alcoholism: Clin Exp Res 11:444–449Google Scholar
  15. Gill K, France C, Amit Z (1986) Voluntary ethanol consumption in rats: an examination of blood/brain alcohol levels and behavior. Alcoholism: Clin Exp Res 10:457–462Google Scholar
  16. Hubbell CL, Czirr SA, Hunter GA, Beaman CM, LeCann NC, Reid LD (1986) Consumption of ethanol solution is potentiated by morphine and attenuated by naloxone persistently across repeated daily administrations. Alcohol 3:39–54CrossRefPubMedGoogle Scholar
  17. Hubbell CL, Czirr SA, Reid LD (1987) Persistence and specificity of small doses of morphine on intake of alcoholic beverages. Alcohol 4:149–156CrossRefPubMedGoogle Scholar
  18. Kiianmaa K, Andersson K, Fuxe K (1979) On the role of ascending dopamine systems in the control of voluntary ethanol intake and ethanol intoxication. Pharmacol Biochem Behav 10:603–608CrossRefPubMedGoogle Scholar
  19. Linseman MA (1987) Alcohol consumption in free-feeding rats: procedural, genetic and pharmacokinetic factors. Psychopharmacology 92:254–261CrossRefPubMedGoogle Scholar
  20. Linseman MA (1988) Consumption of alcohol compared to another bitter solution in a limited access drinking paradigm. Alcohol 5:301–303CrossRefPubMedGoogle Scholar
  21. Linseman MA (1989) Central vs. peripheral mediation of opioid effects on alcohol consumption in free-feeding rats. Pharmacol Biochem Behav 33:401–413CrossRefPubMedGoogle Scholar
  22. Mudar PJ, LeCann NC, Czirr SA, Hubbell CL, Reid LD (1986) Methadone, pentobarbital, pimozide and ethanol-intake. Alcohol 3:303–308CrossRefPubMedGoogle Scholar
  23. Myers RD, Melchior CL (1975) Alcohol drinking in the rat after destruction of serotonergic and catecholaminergic neurons in the brain. Res Commun Chem Pathol Pharmacol 10:363–378PubMedGoogle Scholar
  24. Pfeffer AO, Samson HH (1985) Oral ethanol reinforcement in the rat: effects of acute amphetamine. Alcohol 2:693–697CrossRefPubMedGoogle Scholar
  25. Pfeffer AO, Samson HH (1986) Effect of pimozide on home cage ethanol drinking in the rat: dependence on drinking session length. Drug Alcohol Depend 17:547–555Google Scholar
  26. Pfeffer AO, Samson HH (1988) Haloperidol and apomorphine effects on ethanol reinforcement in free-feeding rats. Pharmacol Biochem Behav 29:343–350CrossRefPubMedGoogle Scholar
  27. Snodgrass SH, Allen JD (1987) Effect of dopamine agents on schedule-and deprivation-induced drinking in rats. Pharmacol Biochem Behav 27:463–475CrossRefPubMedGoogle Scholar
  28. Spyraki C, Fibiger HC (1988) A role for the mesolimbic dopamine system in the reinforcing properties of diazepam. Psychopharmacology 94:133–137CrossRefPubMedGoogle Scholar
  29. Spyraki C, Fibiger HC, Phillips AG (1982a) Dopaminergic substrates of amphetamine-induced place preference conditioning. Brain Res 253:185–193CrossRefPubMedGoogle Scholar
  30. Spyraki C, Fibiger HC, Phillips AG (1982b) Attenuation by haloperidol of place preference conditioning using food reinforcement. Psychopharmacology 77:379–382CrossRefPubMedGoogle Scholar
  31. Spyraki C, Fibiger HC, Phillips AG (1983) Attenuation of heroin reward in rats by disruption of the mesolimbic dopamine system. Psychopharmacology 79:278–283CrossRefPubMedGoogle Scholar
  32. White LK, Carpenter M, Block M, Basse-Tomuisk A, Gardiner TW, Rebec GV (1988) Ascorbate antagonizes the behavioral effects of amphetamine by a central mechanism. Psychopharmacology 94:284–287CrossRefPubMedGoogle Scholar
  33. Wise RA (1980) Action of drugs of abuse on brain reward systems. Pharmacol Biochem Behav 13 Suppl 1:213–223PubMedGoogle Scholar
  34. Wise RA, Bozarth M (1987) A psychomotor stimulant theory of addiction. Psychol Rev 94:469–492CrossRefPubMedGoogle Scholar
  35. Wood PL (1983) Opioid regulation of CNS dopaminergic pathways: A review of methodology, receptor types, regional variations and species differences. Peptides 4:595–601CrossRefPubMedGoogle Scholar
  36. Woolverton WL (1986) Effects of a D1 and a D2 dopamine antagonist on the self-administration of cocaine and piribedil by rhesus monkeys. Pharmacol Biochem Behav 24:531–535CrossRefPubMedGoogle Scholar
  37. Yokel RA, Wise RA (1976) Attenuation of intravenous amphetamine reinforcement by central dopamine blockade in rats. Psychopharmacology 48:311–318CrossRefPubMedGoogle Scholar
  38. York JL (1978) A comparison of the discriminative stimulus effects of ethanol, barbital, and phenobarbital in rats. Psychopharmacology 60:19–23CrossRefPubMedGoogle Scholar

Copyright information

© Springer-Verlag 1990

Authors and Affiliations

  • M. A. Linseman
    • 1
  1. 1.Biobehavioral Studies DepartmentAddiction Research FoundationTorontoCanada

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