Psychopharmacology

, Volume 113, Issue 1, pp 51–52

Reinforcing effect of the D1 dopamine agonist SKF 81297 in rhesus monkeys

  • Michael R. Weed
  • Kimberly E. Vanover
  • William L. Woolverton
Original Investigations

Abstract

Rhesus monkeys with IV catheters were allowed to self-administer cocaine for 1 h/day. When responding was stable, saline or the D1 dopamine agonist SKF 81297 (SKF; 0.001–0.3 mg/kg/inj) was substituted for cocaine. At least two doses of SKF maintained responding above saline levels in all monkeys. The D1 antagonist SCH 39166 (0.001–0.03 mg/kg, IM) was then administered 30 min before sessions of self-administration of the lowest dose of SKF that maintained behavior (0.01 mg/kg/inj). SKF-maintained responding decreased in a dose-related manner, suggesting antagonism of the reinforcing effect. These results suggest that stimulation of D1 receptors can initiate a reinforcing effect and further implicate D1 receptors in the reinforcing effects of drugs that increase dopamine neurotransmission.

Key words

Self-administration Dopamine D1 receptors 

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Copyright information

© Springer-Verlag 1993

Authors and Affiliations

  • Michael R. Weed
    • 1
  • Kimberly E. Vanover
    • 2
  • William L. Woolverton
    • 1
    • 2
    • 3
  1. 1.Department of Pharmacological and Physiological SciencesUniversity of ChicagoChicagoUSA
  2. 2.Committee on BiopsychologyUniversity of ChicagoChicagoUSA
  3. 3.Department of Psychiatry, Drug Abuse Research Center, Pritzker School of MedicineUniversity of ChicagoChicagoUSA
  4. 4.Lederle Laboratories, CNS Research Department, Medical Research DivisionAmerican Cyanamid CompanyPearl RiverUSA

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