, Volume 105, Issue 2, pp 151–156 | Cite as

Effects of selective D1 and D2 dopamine antagonists on cocaine self-administration in the rat

  • Carol B. Hubner
  • J. Edward Moreton
Original Investigations


The effect of the selective D1 antagonist, SCH 23390, and the selective D2 antagonist, spiperone, was investigated in rats trained to self-administer intravenous cocaine on a fixed-ratio (FR) 5 schedule of reinforcement. Both SCH 23390 and spiperone pretreatment increased responding up to doses of 10.0 µg/kg, and decreased responding at higher doses. Since rate of responding maintained by a drug can be influenced by factors other than its reinforcing efficacy, behavior maintained by cocaine was also investigated under a progressive-ratio schedule. The breaking point obtained under this schedule is used as a measure of the efficacy of the reinforcer and this value is not exclusively determined by response rate. With the progressive-ratio schedule, both SCH 23390 and spiperone produced dose-dependent decreases in the highest ratio completed in rats self-administering cocaine. The results obtained using the FR 5 and progressive-ratio schedules suggest that both D1 and D2 receptors are involved in mediating the reinforcing effects of cocaine.

Key words

SCH 23390 Spiperone Cocaine Self-administration Dopamine Fixed-ratio schedule Progressive-ratio schedule 


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Copyright information

© Springer-Verlag 1991

Authors and Affiliations

  • Carol B. Hubner
    • 1
  • J. Edward Moreton
    • 1
  1. 1.Department of Pharmacology and ToxicologyUniversity of Maryland School of PharmacyBaltimoreUSA

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