Psychopharmacology

, Volume 103, Issue 2, pp 271–276

Place conditioning with dopamine D1 and D2 agonists injected peripherally or into nucleus accumbens

  • Norman M. White
  • Mark G. Packard
  • Noboru Hiroi
Original Investigations

DOI: 10.1007/BF02244216

Cite this article as:
White, N.M., Packard, M.G. & Hiroi, N. Psychopharmacology (1991) 103: 271. doi:10.1007/BF02244216

Abstract

The conditioned place preference technique was used to assess the affective properties of the direct dopamine D1 agonist, SKF38393, and the direct D2 agonist, LY171555 (quinpirole). A three compartment apparatus was used: the animals' pre-experimental preference for the two choice compartments was equal and, within each experimental group, half the rats received drug pairings in each choice compartment. Intraperitoneal injections of SKF38393 produced conditioned place aversions at all doses tested (1.0–4.0 mg/kg); LY171555 produced weak conditioned place preferences at 1.0 and 2.0 mg/kg, but no reliable effect at 4.0 mg/kg. Bilateral intra-accumbens microinjections of SKF38393 produced strong preferences at all doses tested (0.5–2.0 µg/side); LY171555 produced strong preferences at two doses (0.5 and 1.0 µg/side) and no effect at a third dose (2.0 µg/side). These results suggest that activation of either D1 or D2 receptors in the nucleus accumbens can produce reward, and that D1 receptors (and possibly also D2 receptors) located elsewhere in the brain or in the periphery may mediate aversive effects.

Key words

Conditioned place preference Dopamine SKF38393 LY171666 Nucleus accumbens 

Copyright information

© Springer-Verlag 1991

Authors and Affiliations

  • Norman M. White
    • 1
  • Mark G. Packard
    • 1
  • Noboru Hiroi
    • 1
  1. 1.Department of PsychologyMcGill UniversityMontrealCanada

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