Psychopharmacology

, Volume 101, Issue 2, pp 233–239

Free choice ethanol intake of laboratory rats under different social conditions

  • Jochen Wolffgramm
Original Investigations
  • 119 Downloads

Abstract

To study the effects of different kinds of social deprivation on voluntary ethanol (ETOH) intake male Wistar rats were housed by (a) individual caging, (b) “contact” caging (partial social deprivation), and (c) group caging (four individuals per cage). In the latter condition the individuals were separated once a week from each other for 24 h. The rats simultaneously received water 5%, 10% and 20% ETOH for a period of 14 weeks. Additional control animals received water. Isolated individuals drank significantly more alcohol than group-housed or contact-caged rats. After a few days they preferred the 20% solution. Circadian measures revealed a discontinuous intake of high doses (> 0.5 g/kg/h) during short time periods. Contact-caged rats consumed much less ETOH, but both the preference for 20% ETOH and the circadian course of intake were similar to those occurring after isolation. ETOH intake of group-housed individuals was low. These individuals preferred the 5% solution and continuously consumed small ETOH doses. During the period of short-term isolation they drank even more ETOH than long-term isolated individuals. In contrast to the latter, the enhancement of intake decreased after some weeks. It is suggested that the differences between the housing groups not only reflect different degrees of isolation stress, but may also be explained by a contribution of different reinforcing or aversive psychotropic effects of ETOH. Reduction of isolation stress is probably most important in the situation of short term separation, whereas dose-dependent reinforcement via social stimulation or sedation may affect the drug taking behavior under the other social conditions.

Key words

Ethanol Drug taking behavior Isolation Stress Rat 

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References

  1. Aragon CMG, Abitol M, Amit Z (1986) Acetaldehyde may mediate reinforcement and aversion produced by ethanol. Neuropharmacology 25:79–83Google Scholar
  2. Bolin P, DaVanzo IP (1982) The influence of isolation and aminooxyacetic acid (AOAA) on GABA in muricidal rats. Psychopharmacology 76:267–370Google Scholar
  3. Carey RI (1972) A decrease in ethanol preference in rats resulting from forced ethanol drinking under fluid deprivation. Physiol Behav 8:373–375Google Scholar
  4. Casey A (1960) The effect of stress on the consumption of alcohol and reserpine. Q J Stud Alcohol 21:208–216Google Scholar
  5. Clark R, Polish E (1960) Avoidance conditioning and alcohol consumption in rhesus monkeys. Science 132:223–224Google Scholar
  6. Clay M (1964) Conditions affecting voluntary alcohol consumption in rats. J Stud Alcohol 25:36–55Google Scholar
  7. Cutler MG, Mackintosh IH, Chance MRA (1975) Effects of the environment on the behavioral response of mice to non-ataxic doses of ethyl alcohol. Neuropharmacology 14:841–846Google Scholar
  8. Dalrymple-Alford IC, Benton D (1981) Activity differences of individually and group-housed male and female rats. Anim Learn Behav 9:50–55Google Scholar
  9. DeTurck H, Vogel WH (1982) Effects of acute ethanol on plasma and brain catecholamine levels in stressed and unstressed rats: evidence for an ethanol-stress interaction. J Pharmacol Ther 223:348–354Google Scholar
  10. Daoust M, Chretien P, Moore N, Saligant C, Lhuintre JP, Boismare F (1985) Isolation and striatal3H serotonin uptake: role in the voluntary intake of ethanol by rats. Pharmacol Biochem Behav 22:205–208Google Scholar
  11. Deatherage G (1972) Effects of housing density on alcohol intake in the rat. Physiol Behav 9:55–57Google Scholar
  12. Einon DF, Humphreys AP, Chivers SM, Field S, Naylor V (1980) Isolation has permanent effects upon the behavior of the rat, but not the mouse, gerbil or guinea pig. Dev Psychobiol 14:343–355Google Scholar
  13. Erickson CK, Kochhar A (1985) An animal model for low dose ethanol-induced locomotor stimulation: behavioral characteristics. Alcohol Clin Exp Res 9:310–314Google Scholar
  14. Frye GD, Breese GR (1981) An evaluation of the locomotor stimulating action of ethanol in rats and mice. Psychopharmacology 75:372–379Google Scholar
  15. Gentsch C. Lichtsteiner M, Feer H (1982) Behavioral comparisons between individually- and group-housed male rats: effects of novel environment and diurnal rhythm. Behav Brain Res 6:93–100Google Scholar
  16. Hatch A, Wiberg GS, Balazs T, Grice HC (1963) Long term isolation stress in rat. Science 142:507Google Scholar
  17. Kraemer GW, McKinney WT (1985) Social separation increases alcohol consumption in rhesus monkeys. Psychopharmacology 86:182–189Google Scholar
  18. Kulkosky PJ, Zellner DA, Hyson RS, Riley AL (1980) Ethanol consumption of rats in individual, group and colonial housing conditions. Physiol Psychol 8:56–60Google Scholar
  19. Lange FH (1962) Korrelationselektronik, 2nd edn. VEB Verlag Technik, BerlinGoogle Scholar
  20. Latané B, Nesbitt P, Eckman J, Rodin J (1972) Long-and short-term social deprivation and sociability in rats. J Comp Physiol Psychol 81:69–75Google Scholar
  21. Li TK, Lumeng L, McBride WJ, Waller MB, Hawkins TD (1979) Progress toward a voluntary oral consumption model of alcoholism. Drug Alcohol Depend 4:45–60Google Scholar
  22. Lovely RH, Pagano RR, Padino RM (1972) Shuttle-box-avoidance performance and basal corticosterone levels as a function of duration of individual housing in rats. J Comp Physiol Psychol 81:331–335Google Scholar
  23. McGuire MT, Raleigh MI (1985) Serotonin-behavior interactions in Vervet monkeys. Psychopharmacol Bull 21:458–463Google Scholar
  24. Mendelson IH, Mello NK (1964) Ethanol and whiskey patterns in rats under free-choice and forced-choice conditions. Q J Stud Alcohol 25:79–83Google Scholar
  25. Mello NK (1983) The pathogenesis of alcoholism. In: Kissin B, Begleiter H (eds) The biology of alcoholism, vol 7. Plenum Press, New York, pp 174–185Google Scholar
  26. Miczek KA, Barry H III (1977) Effects of alcohol on attack and defensive-submissive reactions in rats. Psychopharmacology 52:231–237Google Scholar
  27. Miczek KA, O'Donnell IM (1980) Alcohol and chlordiazepoxide increase suppressed aggression in mice. Psychopharmacology 69:39–44Google Scholar
  28. Myers RD, Holmann RB (1967) Failure of stress of electric shock to increase ethanol intake in rats. Q J Stud Alcohol 28:132–137Google Scholar
  29. Myers RD, Veale WL (1972) The determinants of alcohol preference in animals. In: Kissin B, Begleiter H (eds) The biology of alcoholism, vol 2. Plenum Press, New York, pp 131–163Google Scholar
  30. Nash JF, Maickel RP (1985) Stress-induced consumption of ethanol by rats. Life Sci 37:757–765Google Scholar
  31. Panksepp J (1981) The ontogeny of play in rats. Dev Psychobiol 14:327–332Google Scholar
  32. Persensky JJ, Senter RJ, Jones RB (1969) Alcohol consumption in rats after experimentally induced neurosis. Psychol Sci 15:159–160Google Scholar
  33. Rommelspacher H, Büchau C, Weiss J (1987) Harman induces preference for ethanol in rats: is the effect specific for ethanol? Pharmacol Biochem Behav 26:749–755Google Scholar
  34. Rosenzweig M, Bennett E (1972) Cerebral changes in rats exposed individually to an enriched environment. J Comp Physiol Psychol 80:331–335Google Scholar
  35. Sachser N (1986) The effects of long-term-isolation on physiology and behavior in male guinea pigs. Physiol Behav 38:31–39Google Scholar
  36. Samson HH, Pfeffer AD, Tolliver GA (1988) Oral ethanol self-administration in rats: models of alcohol-seeking behavior. Alcoholism 12:591–598Google Scholar
  37. Stewart RB, Perlanski E, Grupp LA (1988) Ethanol as a reinforcer for rats: factors of facilitation and constraint. Alcoholism 12:599–608Google Scholar
  38. Veale WL, Myers RD (1969) Increased alcohol preference in rats following repeated exposures to alcohol. Psychopharmacologia 15:361–372Google Scholar
  39. Wayner MI, Greenberg I, Tartaglione R, Nolley D, Fraley S, Cott A (1972) A new factor affecting the consumption of ethyl alcohol and other sapid fluids. Physiol Behav 8:345–362Google Scholar

Copyright information

© Springer-Verlag 1990

Authors and Affiliations

  • Jochen Wolffgramm
    • 1
  1. 1.Institute for NeuropsychopharmacologyFree UniversityBerlin 19

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