Psychopharmacology

, Volume 103, Issue 1, pp 41–45 | Cite as

Age-related changes in human D1 dopamine receptors measured by positron emission tomography

  • T. Suhara
  • H. Fukuda
  • O. Inoue
  • T. Itoh
  • K. Suzuki
  • T. Yamasaki
  • Y. Tateno
Original Investigations

Abstract

The effects of age on the binding parameters of11C-SCH23390, the highly selective ligand for central D1 dopamine receptors, at specific binding sites in the brain were studied. Seventeen healthy male volunteers (20–72 years old) participated. Regional radioactivity in the brain was followed for 40 min by positron emission tomography (PET). A high accumulation of radioactivity was observed in the striatum and there was a conspicuous accumulation in the neocortex. A two-compartment model was used to obtain quantitative estimates of rate constants of association (k3) and dissociation (k4). The binding potential (k3/k4) of the dopamine D1 receptors in the striatum and frontal cortex decreased by 35% and 39%, respectively, with age. The value of k3 decreased by 58% in the striatum and 83% in the frontal cortex, whereas the value of k4 decreased by 35% in the striatum and 72% in the frontal cortex with age.

Key words

Positron emission tomography Dopamine D1 receptor SCH23390 Aging Striatum Frontal cortex 

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Copyright information

© Springer-Verlag 1991

Authors and Affiliations

  • T. Suhara
    • 1
  • H. Fukuda
    • 1
  • O. Inoue
    • 1
  • T. Itoh
    • 2
  • K. Suzuki
    • 1
  • T. Yamasaki
    • 1
  • Y. Tateno
    • 1
  1. 1.Division of Clinical ResearchNational Institute of Radiological SciencesChiba-shiJapan
  2. 2.Department of MathematicsNihon Medical SchoolKawasaki-shiJapan

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