Psychopharmacology

, Volume 100, Issue 4, pp 558–559

Antianxiety effect of cannabidiol in the elevated plus-maze

  • F. S. Guimarães
  • T. M. Chiaretti
  • F. G. Graeff
  • A. W. Zuardi
Rapid Communications

Abstract

In order to assess the presence of anxiolytic properties in cannabidiol (CBD) the drug was tested in an elevated plus-maze model of anxiety, in rats. Doses of 2.5, 5.0 and 10.0 mg/kg significantly increased the entry ratio (open/total number of entries), an anxiolytic-like effect. CBD at a dose of 20.0 mg/kg was no longer effective. None of the doses of CBD used changed total number of entries, a measure of total exploratory activity. Diazepam (2.0 mg/kg) also caused an anxiolytic-like effect in this model. These results indicate that CBD causes a selective anxiolytic effect in the elevated plusmaze, within a limited range of doses.

Key words

Cannabidiol Anxiety Elevated plus-maze 

Copyright information

© Springer-Verlag 1990

Authors and Affiliations

  • F. S. Guimarães
    • 1
  • T. M. Chiaretti
    • 1
  • F. G. Graeff
    • 3
  • A. W. Zuardi
    • 2
  1. 1.Department of PharmacologyCampus of the University of São PauloRibeirão PretoBrazil
  2. 2.Department of NeuropsychiatryFMRP, Campus of the University of São PauloRibeirão PretoBrazil
  3. 3.Laboratory of Psychobiology, FFCLRPCampus of the University of São PauloRibeirão PretoBrazil

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