The American Journal of Digestive Diseases

, Volume 9, Issue 2, pp 160–169 | Cite as

Constitutional hyperbilirubinemia with unconjugated bilirubin in the serum and pigment deposition in the liver

Report of a case
  • John D. Herman
  • Everett B. Cooper
  • Akio Takeuchi
  • Helmuth Sprinz
Case Reports


A case of constitutional hyperbilirubinemia with mild elevations of un-conjugated bilirubin in the serum was reported which was further characterized by an accumulation of pigment granules in the liver cells of the Dubin-Johnson-Sprinz-Nelson type. Electron-microscopic studies demonstrated predominantly lipofuscin-like pigments in the liver cells. The pathogenesis of this condition and the chemical nature of these pigments were briefly discussed. Attention was called to a variant of the Gilbert-Meulengracht syndrome.


Public Health Liver Cell Bilirubin Chemical Nature Pigment Granule 
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Copyright information

© Hoeber Medical Division • Harper & Row, Publishers, Incorporated 1964

Authors and Affiliations

  • John D. Herman
    • 1
    • 2
  • Everett B. Cooper
    • 1
    • 2
  • Akio Takeuchi
    • 1
    • 2
  • Helmuth Sprinz
    • 1
    • 2
  1. 1.From the Departments of Hospital Clinics and Internal MedicineWalter Reed General HospitalWashington, D. C.
  2. 2.the Department of Experimental PathologyWalter Reed Army Institute of ResearchWashington, D. C.

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