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The American Journal of Digestive Diseases

, Volume 9, Issue 2, pp 160–169 | Cite as

Constitutional hyperbilirubinemia with unconjugated bilirubin in the serum and pigment deposition in the liver

Report of a case
  • John D. Herman
  • Everett B. Cooper
  • Akio Takeuchi
  • Helmuth Sprinz
Case Reports

Summary

A case of constitutional hyperbilirubinemia with mild elevations of un-conjugated bilirubin in the serum was reported which was further characterized by an accumulation of pigment granules in the liver cells of the Dubin-Johnson-Sprinz-Nelson type. Electron-microscopic studies demonstrated predominantly lipofuscin-like pigments in the liver cells. The pathogenesis of this condition and the chemical nature of these pigments were briefly discussed. Attention was called to a variant of the Gilbert-Meulengracht syndrome.

Keywords

Public Health Liver Cell Bilirubin Chemical Nature Pigment Granule 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Hoeber Medical Division • Harper & Row, Publishers, Incorporated 1964

Authors and Affiliations

  • John D. Herman
    • 1
    • 2
  • Everett B. Cooper
    • 1
    • 2
  • Akio Takeuchi
    • 1
    • 2
  • Helmuth Sprinz
    • 1
    • 2
  1. 1.From the Departments of Hospital Clinics and Internal MedicineWalter Reed General HospitalWashington, D. C.
  2. 2.the Department of Experimental PathologyWalter Reed Army Institute of ResearchWashington, D. C.

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