The American Journal of Digestive Diseases

, Volume 11, Issue 9, pp 671–684 | Cite as

Secretion of pancreatic enzymes

I. Response to secretin and pancreozymin
  • Leslie Zieve
  • Stephen E. Silvis
  • Beatrice Mulford
  • William D. Blackwood
  • Ann McHale
  • William Doizaki
Article

Summary

Pancreatic function was evaluated by measurement of the amount of amylase, lipase, phospholipase A, trypsin, chymotrypsin, and carboxypeptidase activity secreted into the duodenum during a half-hour period following the simultaneous infusion of secretin and pancreozymin. In normal subjects, all but a few resting values for enzyme secretion were less than the lowest value following stimulation with the hormones. The procedure was highly effective in detecting known cases of chronic pancreatitis and carcinoma of the pancreas, in demonstrating pancreatic dyfunction in a variety of parapancreatic diseases, and in excluding pancreatic disease when suspected but not present. A significant but not a high correlation was observed among the enzymes secreted, the best correlations being among patients with known chronic pancreatitis and carcinoma of the pancreas. Many discrepancies in individual cases with other primary diagnoses exemplify the usefulness of more than one enzyme determination.

Keywords

Public Health Enzyme Carcinoma Lipase Pancreatitis 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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Copyright information

© Hoeber Medical Division • Harper & Row, Publishers, Incorporated 1966

Authors and Affiliations

  • Leslie Zieve
    • 1
  • Stephen E. Silvis
    • 1
  • Beatrice Mulford
    • 1
  • William D. Blackwood
    • 1
  • Ann McHale
    • 1
  • William Doizaki
    • 1
  1. 1.From the Laboratory for Cancer Research and Gastroenterology Section, Department of Medicine, Minneapolis Veterans HospitalUniversity of MinnesotaMinneapolis

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