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Jaundice with persisting pericholangiolitic inflammation in a patient treated with chlorothiazide

Report of a case

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Summary

The occasional occurrence of jaundice in patients taking various drugs is well known. Frequently, however, data are insufficient in a suspected case to establish a causal relationship.

Jaundice and pericholangiolitic inflammation of acute nature were demonstrated in a patient treated with chlorothiazide, and it is the author's contention that the changes were relative to the chlorothiazide. Follow-up examination at autopsy 16 months after the episode of jaundice showed irreversible fibrotic pericholangiolitic changes with proliferation of interlobular bile ducts and regeneration of liver parenchymal cells.

Liver function studies at the time of the transient jaundice revealed obstructive features, and later the abnormalities also indicated parenchymal-cell disorder.

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References

  1. 1.

    Klatskin, G. Toxic and drug-induced hepatitis. InDiseases of the Liver (ed. 2). L. Schiff, Ed. Lippincott, Philadelphia, 1963.

  2. 2.

    Drerlp, A. L., Alexander, W. A., Lumb, G. D., Cummins, A. J., andClark, G. M. Jaundice occurring in a patient treated with chlorothiazide.New England J. Med. 259:534. 1958.

  3. 3.

    Pratt, E. B., andAikawa, J. K. Secretion and effect of hydro-chlorothiazide in bile and pancreatic juice.Am. J. Physiol. 202:1083, 1962.

  4. 4.

    Gutman, A. B. Drug reactions characterized by cholestasis associated with intra hepatic biliary tract obstruction.Am. J. Med. 23:841, 1957.

  5. 5.

    Popper, H., Rubin, E., andSchaffner, F. The problem of primary biliary cirrhosis.Am. J. Med. 33: 807, 1962.

  6. 6.

    Myers, J. D., Olson, R. E., Lewis, H., andMoran, J. T. Xanthomatous biliary cirrhosis following chlorpromazine, with observations indicating over-production of cholesterol, hyperprothrombinemia, and the development of portal hypertension.Tr. A. Am. Physiciuns 70:243, 1957.

  7. 7.

    Read, A. E., Harrison, C. V., andSherlock, S. Chronic chlorpromazine jaundice with particular reference to its relationship to primary biliary cirrhosis.Am. J. Med. 31: 249, 1961.

  8. 8.

    Nørredam, K. Chlorpromazine jaundice of long duration.Acta med. scandinav. 174:163, 1963.

  9. 9.

    Watson, C. J., andHofubaler, F. W. The problem of prolonged hepatitis with particular reference to the cholangiolitic type and to the development of cholangiolitic cirrhosis of the liver.Ann. Int. Med. 25:195, 1946.

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Additional information

Dr. Robert L. Woodburn performed the autopsy and rendered invalnable help in the preparation of this report.

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Husebye, K.O. Jaundice with persisting pericholangiolitic inflammation in a patient treated with chlorothiazide. Digest Dis Sci 9, 439–446 (1964). https://doi.org/10.1007/BF02239339

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Keywords

  • Public Health
  • Bile Duct
  • Liver Function
  • Causal Relationship
  • Parenchymal Cell