A possible explanation for the gastrointestinal mucosal lesion in immunoglobulin deficiency state
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Abstract
A patient with immunoglobulin deficiency is reported in whom intestinal biopsies over a 6-year period showed progression from a nearly normal mucosal villous structure to a flat mucosal lesion, a finding not previously reported. Detailed light and electron microscopic studies of the patient's gastrointestinal mucosal biopsies failed to show evidence that the lesion was related to bacterial or parasitic invasion. However, morphologic evidence was obtained suggesting that the intestinal lesion was related to a viral enteritis. It is postulated that the intestinal cells were infected by a myxovirus, and that this resulted in damage of some intestinal mucosal cells and in slowed growth of others—a reverse cancer effect. The data are not conclusive, and other mechanisms for the lesion must remain under consideration.
Keywords
Public Health Microscopic Study Electron Microscopic Study Intestinal Cell Mucosal Cell
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References
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