Clinical Rheumatology

, Volume 16, Issue 3, pp 305–309

Systemic lupus erythmatosus associated with autoimmune hepatitis two cases with novel autoantibodies to transfer RNA-related antigens

  • T. Satoh
  • M. Hirakata
  • T. Yoshida
  • M. Matsumura
  • K. Miyachi
  • T. Mimori
  • M. Akizuki
Case Report

Summary

Two cases of systemic lupus erythematosus (SLE) with autoimmune hepatitis are reported. Both patients had a mild form of SLE without central nervous system or renal involvement and showed a rapid response to corticosteroid therapy. Neither of them had antibodies to mitochondria, smooth muscle, and liver/kidney microsome-1 related to autoimmune hepatitis. Instead, novel autoantibodies which react with transfer RNA-related antigen were detected. These autoantibodies could be a useful marker for classification of SLE associated with autoimune hepatitis.

Key words

Systemic Lupus Erythematosus Autoimmune Hepatitis Autoantibodies Anti-transfer RNA-related Antibodies 

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Copyright information

© Clinical Rheumatology 1997

Authors and Affiliations

  • T. Satoh
    • 1
  • M. Hirakata
    • 1
  • T. Yoshida
    • 1
  • M. Matsumura
    • 1
  • K. Miyachi
    • 2
  • T. Mimori
    • 1
  • M. Akizuki
    • 1
  1. 1.Section of Rheumatology, Department of Internal MedicineKeio University School of MedicineTokyoJapan
  2. 2.Health and Science Research InstituteYokohamaJapan

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