Age-related changes in brain: II. Positron emission tomography of frontal and temporal lobe glucose metabolism in normal subjects
- 74 Downloads
While many neuropsychological studies have demonstrated age-related performance alterations in tests thought to reflect frontal and temporal lobe function, there is little direct observation and comparison of these hypothesized brain changesin vivo. The cerebral glucose metabolism of frontal, temporal, and cerebellar regions was examined in 40 young (\(\bar X\)=27.5±4.9) and 31 elderly (\(\bar X\)=67.6 ± 8.8) normal males using PET-FDG. Univariate analysis showed age-related metabolic reductions in all frontal and temporal lobe regions. The reductions ranged from 13%–24% with the greatest changes in the frontal lobes. Multiple regression analyses showed a stronger age relationship with frontal lobe than with temporal lobe metabolism. The dorsal lateral frontal lobe was the region that appears to change most within the frontal lobes. Examination of the temporal lobe showed that age contributed equally to the metabolic variance of both the lateral temporal lobe and hippocampus. These results suggest that age-related metabolic changes exist in both frontal and temporal lobes and that the frontal lobe change is greater.
KeywordsPositron Emission Tomography Glucose Metabolism Temporal Lobe Frontal Lobe Metabolic Variance
Unable to display preview. Download preview PDF.
- 1.Kemper T. (1984) Neuroanatomical and neuropathological changes in normal aging and in dementia. In: Clinical Neurology of Aging (ed. ML Albert), Oxford University Press, New York.Google Scholar
- 13.Tsui WT. Multimodal Image Data Analysis System (MIDAS) version 1.0, 1995 (Unpublished Manual).Google Scholar
- 16.de Leon MJ, George AE, Stylopoulos LA, Smith G, Miller DC. (1989) Early marker for Alzheimer's disease: The atrophic hippocampus. The Lancet, 2, 672–673.Google Scholar
- 18.Loessner A, Alavi A, Lewandrowski K, Mozley D, Souder E, Gur R. (1993) Quantitative analysis of regional cerebral function (RCF) in healthy volunteers; normal patterns and change with age [Abstract]. Journal of Nuclear Medicine, 34, 210pGoogle Scholar
- 22.Flicker C, Ferris SH, Crook T, Bartus RT, Reisberg B (1986) Cognitive decline in advanced age: Future directions for the psychometric differentiation of normal and pathological age changes in cognitive function. Developmental Neuropsychology, 2, 309–322.Google Scholar
- 23.Hartley AA. (1992) Attention. In: The Handbook of Aging and Cognition (ed. F.I.M. Craik, T.A. Salthouse), pp 3–49. Lawrence Erlbaum Associates, Hillsdale NJ.Google Scholar
- 24.Salthouse TA. (1992) Reasoning and Spatial Abilities. In: The Handbook of Aging and Cognition (ed. F.I.M. Craik, T.A. Salthouse), pp 167–211. Lawrence Erlbaum Associates, Hillsdale, NJ.Google Scholar