The American Journal of Digestive Diseases

, Volume 15, Issue 7, pp 647–651

Complications of the histalog test of gastric acid secretion

  • J. L. Stoller
  • I. B. Holubitsky
  • R. C. Harrison
  • A. I. Munro
Article

Abstract

This paper describes the complications encountered with the use of betazole hydrochloride in a dose of 2.5 mg/kg body weight as a routine test for the stimulation of gastric secretion in a total of 747 subjects. A review is given of previous work on this subject and our own findings are discussed with special reference to myocardial ischemia. It is suggested that betazole hydrochloride tests be carried out with caution in the presence of coronary artery disease or aortic stenosis, and should be avoided in the presence of severe anemia, since this latter condition is easily correctable before the test is performed.

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References

  1. 1.
    Kay AW: Effect of large doses of histamine on gastric secretion of HCl: augmented histamine test. Brit Med J 2:77–80, 1953PubMedGoogle Scholar
  2. 2.
    Laudano OM, Roncoroni EC: Determination of the dose of Histalog that provokes maximal gastric secretory response. Gastroenterology 49:372–374, 1965PubMedGoogle Scholar
  3. 3.
    Rosiere CE, Grossman MI: Analog of histamine that stimulates gastric acid secretion without other actions of histamine. Science 113:651, 1951Google Scholar
  4. 4.
    Ward S, Gillespie IE, Passero EP, et al: Comparison of histalog and histamine as stimulants for maximal gastric secretion in human subjects and in dogs. Gastroenterology 44:620–626, 1963PubMedGoogle Scholar
  5. 5.
    Zaterka S, Neves DP: Maximal gastric secretion in human subjects after Histalog stimulation. Comparison with augmented histamine test. Gastroenterology 47:251–257, 1964PubMedGoogle Scholar
  6. 6.
    Scobie BA: Histalog (ametazole hydrochloride) as a substitute for histamine in determination of maximal acid output. Brit Med J 1:1287–1288, 1965Google Scholar
  7. 7.
    Wruble LD, Cummins AJ, Goldenberg J, et al: The effect of intravenous histalog on gastric secretion in man. Amer J Dig Dis 12:1087–1090, 1967CrossRefGoogle Scholar
  8. 8.
    Breuer RI, Kirsner JB: Present status of histalog gastric analysis in man. Ann NY Acad Sci 140:882–895, 1967PubMedGoogle Scholar
  9. 9.
    Kirsner JB, Ford H: Gastric secretory response to histalog: one-hour basal and histalog secretion in normal persons and in patients with duodenal and gastric ulcer. J Lab Clin Med 46:307–311, 1955PubMedGoogle Scholar
  10. 10.
    Blum NI, Mayoral LG, Kalser MH: “Augmented” gastric analysis. A word of caution. JAMA 191:339–341, 1965CrossRefPubMedGoogle Scholar
  11. 11.
    Munro AI, Stoller JL: Unpublished dataGoogle Scholar

Copyright information

© Hoeber Medical Division • Harper & Row, Publishers, Incorporated 1970

Authors and Affiliations

  • J. L. Stoller
    • 1
  • I. B. Holubitsky
    • 1
  • R. C. Harrison
    • 1
  • A. I. Munro
    • 1
  1. 1.From the Department of SurgeryUniversity of British Columbia, Vancouver General HospitalVancouver

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