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The American Journal of Digestive Diseases

, Volume 16, Issue 11, pp 1000–1006 | Cite as

Salmonella enteritis

I. Role of reduced gastric secretion in pathogenesis
  • Ralph A. Giannella
  • Selwyn A. Broitman
  • Norman Zamcheck
Article

Abstract

Marked impairment of gastric acid secretion was associated with cholera-like diarrhea in 3 patients with salmonella enteritis. In contrast, 4 patients with normal or near-normal gastric acid secretion exhibited only mild diarrhea. Patients with reduced gastric acid secretion may not effectively reduce the number of ingested salmonellae; thus, greater numbers of viable organisms may be discharged into the intestine, causing severe enteritis. Patients with impaired gastric acid secretion are not only more susceptible to salmonella infection, but are also subject to more severe enteritis.

Keywords

Public Health Diarrhea Gastric Acid Acid Secretion Gastric Acid Secretion 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Hoeber Medical Division • Harper & Row, Publishers, Incorporated 1971

Authors and Affiliations

  • Ralph A. Giannella
    • 1
    • 2
    • 3
  • Selwyn A. Broitman
    • 1
    • 2
    • 3
  • Norman Zamcheck
    • 1
    • 2
    • 3
  1. 1.From the Mallory Gastrointestinal Laboratory; Harvard Medical Unit and the Thorndike Memorial LaboratoryBoston City HospitalUSA
  2. 2.the Department of MedicineHarvard Medical SchoolUSA
  3. 3.the Departments of Microbiology and PathologyBoston University School of MedicineBoston

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