The American Journal of Digestive Diseases

, Volume 16, Issue 11, pp 1000–1006 | Cite as

Salmonella enteritis

I. Role of reduced gastric secretion in pathogenesis
  • Ralph A. Giannella
  • Selwyn A. Broitman
  • Norman Zamcheck


Marked impairment of gastric acid secretion was associated with cholera-like diarrhea in 3 patients with salmonella enteritis. In contrast, 4 patients with normal or near-normal gastric acid secretion exhibited only mild diarrhea. Patients with reduced gastric acid secretion may not effectively reduce the number of ingested salmonellae; thus, greater numbers of viable organisms may be discharged into the intestine, causing severe enteritis. Patients with impaired gastric acid secretion are not only more susceptible to salmonella infection, but are also subject to more severe enteritis.


Public Health Diarrhea Gastric Acid Acid Secretion Gastric Acid Secretion 
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Copyright information

© Hoeber Medical Division • Harper & Row, Publishers, Incorporated 1971

Authors and Affiliations

  • Ralph A. Giannella
    • 1
    • 2
    • 3
  • Selwyn A. Broitman
    • 1
    • 2
    • 3
  • Norman Zamcheck
    • 1
    • 2
    • 3
  1. 1.From the Mallory Gastrointestinal Laboratory; Harvard Medical Unit and the Thorndike Memorial LaboratoryBoston City HospitalUSA
  2. 2.the Department of MedicineHarvard Medical SchoolUSA
  3. 3.the Departments of Microbiology and PathologyBoston University School of MedicineBoston

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