Springer Nature is making SARS-CoV-2 and COVID-19 research free. View research | View latest news | Sign up for updates

A controlled study of outpatient gastric freezing

  • 25 Accesses

  • 3 Citations

Summary and conclusions

In a study of gastric freezing in 188 outpatients, placebo response was as good as response to the the treatment itself, nor were results improved by addition of a modified and simplified postfreeze medical program.

Although gastric freezing does seem to have a desirable physiologic effect on ulcer patients with respect to pain relief and transient depression of gastric acidity, in our expeirence these effects are too brief to be therapeutically useful.

Attempts to prolong such desirable secretory alterations by the use of anticholinergic drugs and antacids were unsuccessful.

This is a preview of subscription content, log in to check access.


  1. 1.

    Perry, G. T., Dunphy, J. V., Fruin, R. C. andLittman, A. Gastric freezing for duodenal ulcer—a double blind study.Gastroenterology 47:6, 1964.

  2. 2.

    Rose, H., Fordtran, J. S., Harrell, R., andFriedman, B. A controlled study of gastric freezing for the treatment of duodenal ulcer.Gastroenterology 47:10, 1964.

  3. 3.

    Karacadag, S., andKlotz, A. P. Gastric “freezing” in peptic ulcer.Ann. Int. Med. 61: 645, 1964.

  4. 4.

    Karacadag, S., andKlotz, A. P. A physiologic Interpretation of gastric freezing in the human.Am. J. Dig. Dis. 9:319, 1964.

  5. 5.

    Klotz, A. P., andChristodoulopoulos, J. B. The secretory physiology of gastric freezing.Am. J. Dig. Dis. 10:31, 1965.

  6. 6.

    Wangensteen, O. H., Peter, E. T., Nicoloff, D. M., Sosin, H., andBernstein, E. F. Achieving “physiological gastrectomy” by gastric freezing.J.A.M.A. 180:439, 1962.

  7. 7.

    Owens, F. J., Brown, C. H., Sullivan, B. H., andTretbar, L. L. Clinical experiences in gastric freezing for peptic ulcer.Clevel and Clin. Quart. 31:1, 1964.

  8. 8.

    McHardy, G., Atik, M., Balart, L., Sekinger, D., McHardy, R., Cradic, H., Roberson, F., andJudice, R. An evaluation of gastric hypothermia.Am. J. Dig. Dis. 9:717, 1964.

  9. 9.

    Karacadag, S., andKlotz, A. P. Side effects and complications of gastric freezing.JAMA. 188:1151, 1964.

  10. 10.

    Karacadag, S., andKlotz, A. P. Multiple gastric freezing.Am. J. Dig. Dis. 10:116, 1965.

Download references

Author information

Additional information

Fellow in Gastroenterology.

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Lubos, M.C., Viril, L.C. & Klotz, A.P. A controlled study of outpatient gastric freezing. Digest Dis Sci 11, 266–271 (1966). https://doi.org/10.1007/BF02233973

Download citation


  • Public Health
  • Placebo
  • Depression
  • Acidity
  • Pain Relief