This report documents the association of metastatic colonic adenocarcinoma and hypoglycemia occurring in a 40-year-old female with long-standing ulcerative colitis. Although there was extensive replacement of liver parenchyma by metastases, minimal impairment of liver-cell function and the sequence of clinical events indicated that the hypoglycemia was primarily due to the widespread neoplasm and not to hepatic insufficiency. Tumor analysis by the radioimmunoassay method failed to identify the presence of insulin. To our knowledge, this is the first report of the association of chronic ulcerative colitis, colonic adenocarcinoma and hypoglycemia.
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The authors wish to thank Dr. D. H. Law for his helpful comments and criticism and Mrs. Mildred Hale for her secretarial assistance.
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Whang, R., Boyden, G.M., Herring, E.B. et al. Chronic ulcerative colitis, colonic adenocarcinoma and hypoglycemia. Digest Dis Sci 16, 45–50 (1971). https://doi.org/10.1007/BF02233791
- Public Health
- Ulcerative Colitis
- Clinical Event