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The role of gastrin in gastroileocolic responses

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Summary

Gastrin II and the gastrin-like pentapeptide, ICI 50,123, increase the segmenting motility of the distal colon when administered in doses which are probably physiologic.

The effect of Gastrin II and the pentapeptide on the small intestine is less definite.

It is suggested that gastrin, the antral hormone, plays a part in the mediation of the gastrocolic responses.

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Additional information

Dr. Logan was supported by a Royal Victoria Hospital Fellowship during the course of this work.

We acknowledge the assistance of our colleagues, J. E. Black, T. G. Parks, J. D. George, B. Hamilton, A. A. Kareim, and S D. Clarke, who kindly agreed to cooperate in the early studies with the gastrin-like preparations.

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Connell, A.M., Logan, C.J.H. The role of gastrin in gastroileocolic responses. Digest Dis Sci 12, 277–284 (1967). https://doi.org/10.1007/BF02233645

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Keywords

  • Public Health
  • Small Intestine
  • Distal Colon
  • Antral Hormone